[HTML][HTML] P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating

H Takeuchi, M Iba, H Inoue, M Higuchi, K Takao… - PloS one, 2011 - journals.plos.org
Tauopathies are neurodegenerative disorders characterized by the accumulation of
abnormal tau protein leading to cognitive and/or motor dysfunction. To understand the …

Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study

T Maruhashi, J Soga, N Fujimura, N Idei, S Mikami… - Heart, 2013 - heart.bmj.com
Objective To determine the relationships between flow-mediated vasodilation (FMD) and
cardiovascular risk factors, and to evaluate confounding factors for measurement of FMD in …

Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation

T Maruhashi, J Soga, N Fujimura, N Idei… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Nitroglycerine-induced vasodilation has been used as a control test for flow-
mediated vasodilation (FMD) to differentiate endothelium-dependent from endothelium …

Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome

T Maruhashi, J Soga, N Fujimura, N Idei, S Mikami… - Circulation, 2012 - Am Heart Assoc
Background—Patients with Gilbert syndrome have mild unconjugated hyperbilirubinemia. It
has been shown that bilirubin is an endogenous antioxidant. We evaluated the role of …

Ratio of serum levels of AGEs to soluble form of RAGE is a predictor of endothelial function

M Kajikawa, A Nakashima, N Fujimura… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE Advanced glycation end products (AGEs) and their specific receptor, the
receptor for AGEs (RAGE), play an important role in atherosclerosis. Recently, a soluble …

Endothelial dysfunction, increased arterial stiffness, and cardiovascular risk prediction in patients with coronary artery disease: FMD‐J (Flow‐Mediated Dilation Japan) …

T Maruhashi, J Soga, N Fujimura, N Idei… - Journal of the …, 2018 - Am Heart Assoc
Background The usefulness of vascular function tests for management of patients with a
history of coronary artery disease is not fully known. Methods and Results We measured …

[HTML][HTML] Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

T Kobayashi, W Piao, T Takamura, H Kori… - Nature …, 2019 - nature.com
Quiescence is important for sustaining neural stem cells (NSCs) in the adult brain over the
lifespan. Lysosomes are digestive organelles that degrade membrane receptors after they …

Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction

S Kishimoto, M Kajikawa, T Maruhashi… - International Journal of …, 2017 - Elsevier
Background Endothelial dysfunction and abnormal vascular structure may be involved in the
pathogenesis of chronic heart failure (HF). The purpose of this study was to evaluate …

Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors

Y Iwamoto, T Maruhashi, Y Fujii, N Idei… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Cardiovascular diseases are associated with impaired flow-mediated
vasodilation (FMD) and increase in carotid intima-media thickness (IMT). Both FMD and IMT …

Combination of flow-mediated vasodilation and nitroglycerine-induced vasodilation is more effective for prediction of cardiovascular events

M Kajikawa, T Maruhashi, E Hida, Y Iwamoto… - …, 2016 - Am Heart Assoc
Measurement of nitroglycerine-induced vasodilation has been performed to differentiate
endothelium-dependent vasodilation from endothelium-independent vasodilation as a …