[HTML][HTML] P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating
Tauopathies are neurodegenerative disorders characterized by the accumulation of
abnormal tau protein leading to cognitive and/or motor dysfunction. To understand the …
abnormal tau protein leading to cognitive and/or motor dysfunction. To understand the …
Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study
T Maruhashi, J Soga, N Fujimura, N Idei, S Mikami… - Heart, 2013 - heart.bmj.com
Objective To determine the relationships between flow-mediated vasodilation (FMD) and
cardiovascular risk factors, and to evaluate confounding factors for measurement of FMD in …
cardiovascular risk factors, and to evaluate confounding factors for measurement of FMD in …
Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation
T Maruhashi, J Soga, N Fujimura, N Idei… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Nitroglycerine-induced vasodilation has been used as a control test for flow-
mediated vasodilation (FMD) to differentiate endothelium-dependent from endothelium …
mediated vasodilation (FMD) to differentiate endothelium-dependent from endothelium …
Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome
T Maruhashi, J Soga, N Fujimura, N Idei, S Mikami… - Circulation, 2012 - Am Heart Assoc
Background—Patients with Gilbert syndrome have mild unconjugated hyperbilirubinemia. It
has been shown that bilirubin is an endogenous antioxidant. We evaluated the role of …
has been shown that bilirubin is an endogenous antioxidant. We evaluated the role of …
Ratio of serum levels of AGEs to soluble form of RAGE is a predictor of endothelial function
M Kajikawa, A Nakashima, N Fujimura… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE Advanced glycation end products (AGEs) and their specific receptor, the
receptor for AGEs (RAGE), play an important role in atherosclerosis. Recently, a soluble …
receptor for AGEs (RAGE), play an important role in atherosclerosis. Recently, a soluble …
Endothelial dysfunction, increased arterial stiffness, and cardiovascular risk prediction in patients with coronary artery disease: FMD‐J (Flow‐Mediated Dilation Japan) …
T Maruhashi, J Soga, N Fujimura, N Idei… - Journal of the …, 2018 - Am Heart Assoc
Background The usefulness of vascular function tests for management of patients with a
history of coronary artery disease is not fully known. Methods and Results We measured …
history of coronary artery disease is not fully known. Methods and Results We measured …
[HTML][HTML] Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
T Kobayashi, W Piao, T Takamura, H Kori… - Nature …, 2019 - nature.com
Quiescence is important for sustaining neural stem cells (NSCs) in the adult brain over the
lifespan. Lysosomes are digestive organelles that degrade membrane receptors after they …
lifespan. Lysosomes are digestive organelles that degrade membrane receptors after they …
Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction
S Kishimoto, M Kajikawa, T Maruhashi… - International Journal of …, 2017 - Elsevier
Background Endothelial dysfunction and abnormal vascular structure may be involved in the
pathogenesis of chronic heart failure (HF). The purpose of this study was to evaluate …
pathogenesis of chronic heart failure (HF). The purpose of this study was to evaluate …
Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors
Y Iwamoto, T Maruhashi, Y Fujii, N Idei… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Cardiovascular diseases are associated with impaired flow-mediated
vasodilation (FMD) and increase in carotid intima-media thickness (IMT). Both FMD and IMT …
vasodilation (FMD) and increase in carotid intima-media thickness (IMT). Both FMD and IMT …
Combination of flow-mediated vasodilation and nitroglycerine-induced vasodilation is more effective for prediction of cardiovascular events
M Kajikawa, T Maruhashi, E Hida, Y Iwamoto… - …, 2016 - Am Heart Assoc
Measurement of nitroglycerine-induced vasodilation has been performed to differentiate
endothelium-dependent vasodilation from endothelium-independent vasodilation as a …
endothelium-dependent vasodilation from endothelium-independent vasodilation as a …