User profiles for "author:Trevor Bedford"

Trevor Bedford

Professor, Fred Hutchinson Cancer Center
Verified email at bedford.io
Cited by 17703

[HTML][HTML] Viral phylodynamics

EM Volz, K Koelle, T Bedford - PLoS computational biology, 2013 - journals.plos.org
Viral phylodynamics is defined as the study of how epidemiological, immunological, and
evolutionary processes act and potentially interact to shape viral phylogenies. Since the …

Nextstrain: real-time tracking of pathogen evolution

J Hadfield, C Megill, SM Bell, J Huddleston… - …, 2018 - academic.oup.com
Understanding the spread and evolution of pathogens is important for effective public health
measures and surveillance. Nextstrain consists of a database of viral genomes, a …

[HTML][HTML] Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain

J Hadfield, AF Brito, DM Swetnam, CBF Vogels… - PLoS …, 2019 - journals.plos.org
It has been 20 years since West Nile virus first emerged in the Americas, and since then,
little progress has been made to control outbreaks caused by this virus. After its first …

Predictive modeling of influenza shows the promise of applied evolutionary biology

DH Morris, KM Gostic, S Pompei, T Bedford… - Trends in …, 2018 - cell.com
Seasonal influenza is controlled through vaccination campaigns. Evolution of influenza virus
antigens means that vaccines must be updated to match novel strains, and vaccine …

[HTML][HTML] SARS-CoV-2 variants in patients with immunosuppression

L Corey, C Beyrer, MS Cohen… - … England Journal of …, 2021 - Mass Medical Soc
SARS-CoV-2 Variants in Patients with Immunosuppression | NEJM Skip to main content NEJM
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Improving the accuracy of demographic and molecular clock model comparison while accommodating phylogenetic uncertainty

G Baele, P Lemey, T Bedford, A Rambaut… - Molecular biology …, 2012 - academic.oup.com
Recent developments in marginal likelihood estimation for model selection in the field of
Bayesian phylogenetics and molecular evolution have emphasized the poor performance of …

Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples

J Quick, ND Grubaugh, ST Pullan, IM Claro, AD Smith… - Nature protocols, 2017 - nature.com
Genome sequencing has become a powerful tool for studying emerging infectious diseases;
however, genome sequencing directly from clinical samples (ie, without isolation and …

The early spread and epidemic ignition of HIV-1 in human populations

NR Faria, A Rambaut, MA Suchard, G Baele, T Bedford… - science, 2014 - science.org
Thirty years after the discovery of HIV-1, the early transmission, dissemination, and
establishment of the virus in human populations remain unclear. Using statistical …

Persistent HIV-1 replication maintains the tissue reservoir during therapy

R Lorenzo-Redondo, HR Fryer, T Bedford, EY Kim… - Nature, 2016 - nature.com
Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site
associated with viral production, storage of viral particles in immune complexes, and viral …

Establishment and cryptic transmission of Zika virus in Brazil and the Americas

NR Faria, J Quick, IM Claro, J Theze, JG de Jesus… - Nature, 2017 - nature.com
Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in
northeast Brazil. Brazil has had the highest number of reported ZIKV cases worldwide (more …