TREM2-ligand interactions in health and disease
The protein triggering receptor expressed on myeloid cells-2 (TREM2) is an
immunomodulatory receptor with a central role in myeloid cell activation and survival. In …
immunomodulatory receptor with a central role in myeloid cell activation and survival. In …
The role of CLCA proteins in inflammatory airway disease
Inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease
(COPD) exhibit stereotyped traits that are variably expressed in each person. In …
(COPD) exhibit stereotyped traits that are variably expressed in each person. In …
[HTML][HTML] Integrated guidance for enhancing the care of familial hypercholesterolaemia in Australia
GF Watts, DR Sullivan, DL Hare, KM Kostner… - Heart, Lung and …, 2021 - Elsevier
Familial hypercholesterolaemia (FH) is a dominant and highly penetrant monogenic
disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) …
disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) …
[PDF][PDF] Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1
During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-
phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) …
phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) …
[HTML][HTML] IL-13–induced airway mucus production is attenuated by MAPK13 inhibition
YG Alevy, AC Patel, AG Romero… - The Journal of …, 2012 - Am Soc Clin Investig
Increased mucus production is a common cause of morbidity and mortality in inflammatory
airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and …
airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and …
TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
Viral infections and type 2 immune responses are thought to be critical for the development
of chronic respiratory disease, but the link between these events needs to be better defined …
of chronic respiratory disease, but the link between these events needs to be better defined …
[PDF][PDF] Accessory protein recruitment motifs in clathrin-mediated endocytosis
Clathrin-mediated endocytosis depends upon the interaction of accessory proteins with the
α-ear of the AP-2 adaptor. We present structural characterization of these regulatory …
α-ear of the AP-2 adaptor. We present structural characterization of these regulatory …
[HTML][HTML] PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection
Y Zhang, D Mao, WT Roswit, X Jin, AC Patel… - Nature …, 2015 - nature.com
Enhancing the response to interferon could offer an immunological advantage to the host. In
support of this concept, we used a modified form of the transcription factor STAT1 to achieve …
support of this concept, we used a modified form of the transcription factor STAT1 to achieve …
[HTML][HTML] Lrp1 is a host entry factor for Rift Valley fever virus
Rift Valley fever virus (RVFV) is a zoonotic pathogen with pandemic potential. RVFV entry is
mediated by the viral glycoprotein (Gn), but host entry factors remain poorly defined. Our …
mediated by the viral glycoprotein (Gn), but host entry factors remain poorly defined. Our …
[HTML][HTML] Data publication with the structural biology data grid supports live analysis
Access to experimental X-ray diffraction image data is fundamental for validation and
reproduction of macromolecular models and indispensable for development of structural …
reproduction of macromolecular models and indispensable for development of structural …