Transforming clinical microbiology with bacterial genome sequencing
Whole-genome sequencing of bacteria has recently emerged as a cost-effective and
convenient approach for addressing many microbiological questions. Here, we review the …
convenient approach for addressing many microbiological questions. Here, we review the …
Within-host evolution of bacterial pathogens
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …
genomic evolution of bacterial pathogens during the colonization and infection of humans …
[HTML][HTML] Effect of Covid-19 vaccination on transmission of alpha and delta variants
DW Eyre, D Taylor, M Purver, D Chapman… - … England Journal of …, 2022 - Mass Medical Soc
Background Before the emergence of the B. 1.617. 2 (delta) variant of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), vaccination reduced transmission of …
respiratory syndrome coronavirus 2 (SARS-CoV-2), vaccination reduced transmission of …
[HTML][HTML] Antibody status and incidence of SARS-CoV-2 infection in health care workers
SF Lumley, D O'Donnell, NE Stoesser… - … England Journal of …, 2021 - Mass Medical Soc
Background The relationship between the presence of antibodies to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the risk of subsequent reinfection …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the risk of subsequent reinfection …
[HTML][HTML] Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK
The effectiveness of the BNT162b2 and ChAdOx1 vaccines against new severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections requires continuous re …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections requires continuous re …
[HTML][HTML] Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
AM Dondorp, CI Fanello, ICE Hendriksen, E Gomes… - The Lancet, 2010 - thelancet.com
Background Severe malaria is a major cause of childhood death and often the main reason
for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established …
for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established …
[HTML][HTML] Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study
TM Walker, CLC Ip, RH Harrell, JT Evans… - The Lancet infectious …, 2013 - thelancet.com
Background Tuberculosis incidence in the UK has risen in the past decade. Disease control
depends on epidemiological data, which can be difficult to obtain. Whole-genome …
depends on epidemiological data, which can be difficult to obtain. Whole-genome …
[HTML][HTML] Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom
The effectiveness of COVID-19 vaccination in preventing new severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infections in the general community is still unclear …
syndrome coronavirus 2 (SARS-CoV-2) infections in the general community is still unclear …
[HTML][HTML] Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom
We report that in a cohort of 45,965 adults, who were receiving either the ChAdOx1 or the
BNT162b2 SARS-CoV-2 vaccines, in those who had no prior infection with SARS-CoV-2 …
BNT162b2 SARS-CoV-2 vaccines, in those who had no prior infection with SARS-CoV-2 …
[HTML][HTML] Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing
Background It has been thought that Clostridium difficile infection is transmitted
predominantly within health care settings. However, endemic spread has hampered …
predominantly within health care settings. However, endemic spread has hampered …