Background The ability to reproduce experiments is a defining principle of science.
Reproducibility of clinical research has received relatively little scientific attention. However …

Lung-protective ventilation (LPV) has become the cornerstone of management in patients
with ARDS. A subset of patients is unable to tolerate LPV without significant CO 2 elevation …

Endonucleolytic cleavage of the coding region determinant (CRD) of c-myc mRNA appears
to play a critical role in regulating c-myc mRNA turnover. Using 32P-labeled c-myc CRD …

The efficient turnover of messenger RNA represents an important mechanism that allows the
cell to control gene expression. Until recently, the mechanism of mRNA decay was mainly …

Introduction Flexible visitation policies in hospitals are an important component of care that
contributes to reduced stress and increased satisfaction among patients and their family …

Cryptococcus is the most important cause of fungal meningitis in immunocompromised
individuals. Host defense against Cryptococcus involves direct killing by NK cells. That NK …

Hypercapnia vs normocapnia in patients with acute respiratory distress syndrome Hypercapnia
vs normocapnia in patients with acute respiratory distress syndrome Br J Hosp Med (Lond) …

Lung protective ventilation has become the cornerstone of management in patients with
ARDS. A subset of patients are unable to tolerate lung protective ventilation without …

There is increasing evidence that mammalian endoribonucleases play a significant role in
the degradation of messenger RNA (mRNA) and are key players in the regulation of gene …

Rationale: existing clinical practices that are low-value is to identify those wherein new
evidence (ie replication research) suggests that an intervention previously thought to be …