Objective To study serious harms associated with selective serotonin and serotonin-
norepinephrine reuptake inhibitors. Design Systematic review and meta-analysis. Main …

Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified
at a later stage. It is one of the major causes of cancer-related deaths globally. The …

OBJECTIVES: Grading of Recommendations Assessment, Development and Evaluation
(GRADE) is a system for rating the confidence in estimates of effect and grading guideline …

Background Delays in diagnosis and treatment of pulmonary tuberculosis are a major set-
back to global tuberculosis control. There is currently no global evidence on the average …

Since its inception in 2003, Cost Effectiveness and Resource Allocation journal has come a
long way over the past 18 years. Possibly much longer than many of its contemporaries in …

Background Acute psychotic illness, especially when associated with agitated or violent
behaviour, can require urgent pharmacological tranquillisation or sedation. In several …

Objectives: Despite international agreement that stopping low value practices will increase
efficiency, identifying them is difficult and controversial. Opponents of centralized lists of low …

Background The use of research evidence as an input for health decision-making is a need
for most health systems. There are a number of approaches for promoting evidence use at …

Objective The objectives of this review were to identify vaccine economic evaluations that
include herd immunity and describe the methodological approaches used. Methods We …

Background This overview aimed to synthesize existing systematic reviews to produce a
draft framework of evidence-informed health priority setting that supports countries in …