Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease

ST Lugg, A Scott, D Parekh, B Naidu, DR Thickett - Thorax, 2022 - thorax.bmj.com
Cigarette smoking is the leading cause of preventable death worldwide. It causes chronic
lung disease and predisposes individuals to acute lung injury and pulmonary infection …

[HTML][HTML] Optimal vitamin D supplementation levels for cardiovascular disease protection

ST Lugg, PA Howells, DR Thickett - Disease Markers, 2015 - hindawi.com
First described in relation to musculoskeletal disease, there is accumulating data to suggest
that vitamin D may play an important role in cardiovascular disease (CVD). In this review we …

[HTML][HTML] Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages

A Scott, ST Lugg, K Aldridge, KE Lewis, A Bowden… - Thorax, 2018 - thorax.bmj.com
Objective Vaping may increase the cytotoxic effects of e-cigarette liquid (ECL). We
compared the effect of unvaped ECL to e-cigarette vapour condensate (ECVC) on alveolar …

Long-term impact of developing a postoperative pulmonary complication after lung surgery

ST Lugg, PJ Agostini, T Tikka, A Kerr, K Adams… - Thorax, 2016 - thorax.bmj.com
Introduction Postoperative pulmonary complications (PPC) such as atelectasis and
pneumonia are common following lung resection. PPCs have a significant clinical impact on …

[HTML][HTML] Risk factors and short-term outcomes of postoperative pulmonary complications after VATS lobectomy

PJ Agostini, ST Lugg, K Adams, T Smith… - Journal of cardiothoracic …, 2018 - Springer
Abstract Background Postoperative pulmonary complications (PPCs) are associated with
poor outcomes following thoracotomy and lung resection. Video-assisted thoracoscopic …

Simvastatin improves neutrophil function and clinical outcomes in pneumonia. A pilot randomized controlled clinical trial

E Sapey, JM Patel, H Greenwood… - American journal of …, 2019 - atsjournals.org
Rationale: Population studies suggest improved sepsis outcomes with statins, but the results
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …

[HTML][HTML] Smoking and timing of cessation on postoperative pulmonary complications after curative-intent lung cancer surgery

ST Lugg, T Tikka, PJ Agostini, A Kerr, K Adams… - Journal of cardiothoracic …, 2017 - Springer
Background Smoking is a risk factor for postoperative pulmonary complications (PPC)
following non-small cell lung cancer (NSCLC) surgery. The optimal timing for preoperative …

Postoperative pulmonary complications and rehabilitation requirements following lobectomy: a propensity score matched study of patients undergoing video-assisted …

P Agostini, ST Lugg, K Adams… - … and thoracic surgery, 2017 - academic.oup.com
OBJECTIVES: Video-assisted thoracoscopic surgical (VATS) lobectomy is increasingly used
for curative intent lung cancer surgery compared to open thoracotomy due to its minimally …

Vitamin D status and seroconversion for COVID-19 in UK healthcare workers

AA Faniyi, ST Lugg, SE Faustini… - European …, 2021 - Eur Respiratory Soc
The coronavirus disease 2019 (COVID-19) pandemic is a global health emergency,
resulting in over 50 million infections and over 1.2 million deaths as of mid-November 2020 …

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis

RY Mahida, A Scott, D Parekh, ST Lugg… - European …, 2021 - Eur Respiratory Soc
Acute respiratory distress syndrome (ARDS) is an inflammatory disorder of the lungs, with
sepsis as the predominant aetiology. Despite advances in ventilation strategies, mortality for …