The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established
roles in lifespan determination and response to caloric restriction. We have studied mice …

The sirt1 gene encodes a protein deacetylase with a broad spectrum of reported substrates.
Mice carrying null alleles for sirt1 are viable on outbred genetic backgrounds so we have …

Background A number of food allergies (eg, fish, shellfish, and nuts) are lifelong, without any
disease-transforming therapies, and unclear in their underlying immunology. Clinical …

In recent years, several new radiotracers and radionuclide therapies have been developed.
There is a renaissance in nuclear medicine and molecular imaging today in terms of, for …

The effects of chronic social stress on hepatic glycogen metabolism were examined in
rainbow trout Oncorhynchus mykiss by comparing hepatocyte glucose production, liver …

Background Mood and anxiety issues are the main mental health complaints of women
during pregnancy and the postpartum period. Services targeting such women can reduce …

Introduction Chronic Myeloid Leukaemia (CML) constitutes 15% of new adult leukaemia
cases as well as 2%–3% of leukaemia in children under 15% and 9% of leukaemias in …

Purpose: To compare limbal and pars plana silicone oil removal (SOR) in aphakic eyes and
to evaluate the acute effect of silicone oil flow to the corneal endothelium. Methods: Sixteen …

Severe sepsis and septic shock represent a major cause of mortality in critical care. Even in
patients who survived, a clinical course complicated with multiple organ dysfunction leads to …

Introduction. Even the most modern technology has failed to induce satisfactory functional
regeneration of traumatically severed peripheral nerves. Delayed neural regeneration and …