User profiles for "author:Samuel Akech"

Samuel Akech

KEMRI-Wellcome Trust Research Programme
Verified email at kemri-wellcome.org
Cited by 10634

[HTML][HTML] Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

CJL Murray, KS Ikuta, F Sharara, L Swetschinski… - The lancet, 2022 - thelancet.com
Background Antimicrobial resistance (AMR) poses a major threat to human health around
the world. Previous publications have estimated the effect of AMR on incidence, deaths …

[HTML][HTML] Criteria for pediatric sepsis—a systematic review and meta-analysis by the pediatric sepsis definition taskforce

K Menon, LJ Schlapbach, S Akech, A Argent… - Critical care …, 2022 - journals.lww.com
Objective: To determine the associations of demographic, clinical, laboratory, organ
dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic …

[HTML][HTML] Mortality after fluid bolus in African children with severe infection

K Maitland, S Kiguli, RO Opoka, C Engoru… - … England Journal of …, 2011 - Mass Medical Soc
Background The role of fluid resuscitation in the treatment of children with shock and life-
threatening infections who live in resource-limited settings is not established. Methods We …

[HTML][HTML] Pediatric sepsis definition—a systematic review protocol by the Pediatric Sepsis Definition Taskforce

K Menon, LJ Schlapbach, S Akech… - Critical care …, 2020 - journals.lww.com
Objectives: Sepsis is responsible for a substantial proportion of global childhood morbidity
and mortality. However, evidence demonstrates major inaccuracies in the use of the term …

Choice of fluids for resuscitation in children with severe infection and shock: systematic review

S Akech, H Ledermann, K Maitland - Bmj, 2010 - bmj.com
Objective To systemically review the evidence from clinical trials comparing the use of
crystalloids and colloids for fluid resuscitation in children with severe infection. Data sources …

[HTML][HTML] Exploring mechanisms of excess mortality with early fluid resuscitation: insightsfrom the FEAST trial

K Maitland, EC George, JA Evans, S Kiguli… - BMC medicine, 2013 - Springer
Background Early rapid fluid resuscitation (boluses) in African children with severe
febrileillnesses increases the 48-hour mortality by 3.3% compared with controls (nobolus) …

A bibliometric analysis of COVID-19 research in Africa

FH Guleid, R Oyando, E Kabia, A Mumbi, S Akech… - BMJ Global …, 2021 - gh.bmj.com
Background The COVID-19 pandemic has led to an unprecedented global research effort to
build a body of knowledge that can inform mitigation strategies. We carried out a bibliometric …

[HTML][HTML] Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness

S Kiguli, K Maitland, EC George, P Olupot-Olupot… - BMC medicine, 2015 - Springer
Background Severe anaemia in children is a leading cause of hospital admission and a
major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood …

[HTML][HTML] Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial

S Akech, S Gwer, R Idro, G Fegan, AC Eziefula… - PLoS clinical …, 2006 - journals.plos.org
Objectives Previous studies have shown that in children with severe malaria, resuscitation
with albumin infusion results in a lower mortality than resuscitation with saline infusion …

Tackling health professionals' strikes: an essential part of health system strengthening in Kenya

G Irimu, M Ogero, G Mbevi, C Kariuki, D Gathara… - BMJ global …, 2018 - gh.bmj.com
InTroduCTIon Since devolution of healthcare services in 2013, the Kenyan public health
sector has been affected by frequent short and often localised strikes. 1 These were followed …