Critical care and the global burden of critical illness in adults

NKJ Adhikari, RA Fowler, S Bhagwanjee… - The Lancet, 2010 - thelancet.com
Critical care has evolved from treatment of poliomyelitis victims with respiratory failure in an
intensive care unit to treatment of severely ill patients irrespective of location or specific …

Eligibility criteria of randomized controlled trials published in high-impact general medical journals: a systematic sampling review

HGC Van Spall, A Toren, A Kiss, RA Fowler - Jama, 2007 - jamanetwork.com
ContextSelective eligibility criteria of randomized controlled trials (RCTs) are vital to trial
feasibility and internal validity. However, the exclusion of certain patient populations may …

Has mortality from acute respiratory distress syndrome decreased over time? A systematic review

J Phua, JR Badia, NKJ Adhikari… - American journal of …, 2009 - atsjournals.org
Rationale: It is commonly stated that mortality from acute respiratory distress syndrome
(ARDS) and acute lung injury (ALI) is decreasing. Objectives: To systematically review the …

Critically ill patients with 2009 influenza A (H1N1) infection in Canada

A Kumar, R Zarychanski, R Pinto, DJ Cook, J Marshall… - Jama, 2009 - jamanetwork.com
Context Between March and July 2009, the largest number of confirmed cases of 2009
influenza A (H1N1) infection occurred in North America. Objective To describe …

[HTML][HTML] Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention

SD Solomon, JJV McMurray, MA Pfeffer… - … England Journal of …, 2005 - Mass Medical Soc
Background Selective cyclooxygenase-2 (COX-2) inhibitors have come under scrutiny
because of reports suggesting an increased cardiovascular risk associated with their use …

Critically ill patients with 2009 influenza A (H1N1) in Mexico

G Domínguez-Cherit, SE Lapinsky, AE Macias, R Pinto… - Jama, 2009 - jamanetwork.com
Context In March 2009, novel 2009 influenza A (H1N1) was first reported in the
southwestern United States and Mexico. The population and health care system in Mexico …

Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome

YM Arabi, Y Mandourah, F Al-Hameed… - American journal of …, 2018 - atsjournals.org
Rationale: Corticosteroid therapy is commonly used among critically ill patients with Middle
East Respiratory Syndrome (MERS), but its impact on outcomes is uncertain. Analyses of …

Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis

P Domingo, I Mur, GM Mateo, M del Mar Gutierrez… - Jama, 2021 - jamanetwork.com
Importance Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized
for COVID-19 have variously reported benefit, no effect, and harm. Objective To estimate the …

Care for critically ill patients with COVID-19

S Murthy, CD Gomersall, RA Fowler - Jama, 2020 - jamanetwork.com
Initial reports suggest that COVID-19 is associated with severe disease that requires
intensive care in approximately 5% of proven infections. 1 Given how common the disease …

[HTML][HTML] Celecoxib for the prevention of colorectal adenomatous polyps

N Arber, CJ Eagle, J Spicak, I Rácz… - … England Journal of …, 2006 - Mass Medical Soc
Background Overexpression of cyclooxygenase 2 (COX-2) has been associated with
colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition …