European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium
C Aldecoa, G Bettelli, F Bilotta… - European Journal of …, 2017 - journals.lww.com
The purpose of this guideline is to present evidence-based and consensus-based
recommendations for the prevention and treatment of postoperative delirium. The …
recommendations for the prevention and treatment of postoperative delirium. The …
Unresponsiveness≠ unconsciousness
Consciousness is subjective experience. During both sleep and anesthesia, consciousness
is common, evidenced by dreaming. A defining feature of dreaming is that, while conscious …
is common, evidenced by dreaming. A defining feature of dreaming is that, while conscious …
Biologic effects of nitrous oxide: a mechanistic and toxicologic review
RD Sanders, J Weimann, M Maze… - The Journal of the …, 2008 - pubs.asahq.org
Nitrous oxide is the longest serving member of the anesthesiologist's pharmacologic
armamentarium but remains a source of controversy because of fears over its adverse …
armamentarium but remains a source of controversy because of fears over its adverse …
[HTML][HTML] Spinal anesthesia or general anesthesia for hip surgery in older adults
Background The effects of spinal anesthesia as compared with general anesthesia on the
ability to walk in older adults undergoing surgery for hip fracture have not been well studied …
ability to walk in older adults undergoing surgery for hip fracture have not been well studied …
[HTML][HTML] Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
PP Pandharipande, RD Sanders, TD Girard… - Critical Care, 2010 - Springer
Introduction Benzodiazepines and α 2 adrenoceptor agonists exert opposing effects on
innate immunity and mortality in animal models of infection. We hypothesized that sedation …
innate immunity and mortality in animal models of infection. We hypothesized that sedation …
Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats
RD Sanders, J Xu, Y Shu, A Januszewski… - The Journal of the …, 2009 - pubs.asahq.org
Background Neuroapoptosis is induced by the administration of anesthetic agents to the
young. As alpha2 adrenoceptor signaling plays a trophic role during development and is …
young. As alpha2 adrenoceptor signaling plays a trophic role during development and is …
Dexmedetomidine produces its neuroprotective effect via the α2A-adrenoceptor subtype
D Ma, M Hossain, N Rajakumaraswamy… - European journal of …, 2004 - Elsevier
Which of the three α2-adrenoceptor subtypes of α2A, α2B, or α2C mediates the
neuroprotective effect of dexmedetomidine was examined in cell culture as well as in an in …
neuroprotective effect of dexmedetomidine was examined in cell culture as well as in an in …
[HTML][HTML] Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
J Gu, P Sun, H Zhao, HR Watts, RD Sanders… - Critical care, 2011 - Springer
Introduction Acute kidney injury following surgery incurs significant mortality with no proven
preventative therapy. We investigated whether the α 2 adrenoceptor agonist …
preventative therapy. We investigated whether the α 2 adrenoceptor agonist …
Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
D Ma, M Hossain, A Chow, M Arshad… - Annals of …, 2005 - Wiley Online Library
Perinatal asphyxia can result in neuronal injury with long‐term neurological and behavioral
consequences. Although hypothermia may provide some modest benefit, the intervention …
consequences. Although hypothermia may provide some modest benefit, the intervention …
Withholding versus Continuing Angiotensin-converting Enzyme Inhibitors or Angiotensin II Receptor Blockers before Noncardiac Surgery: An Analysis of the Vascular …
Background The effect on cardiovascular outcomes of withholding angiotensin-converting
enzyme inhibitors or angiotensin II receptor blockers in chronic users before noncardiac …
enzyme inhibitors or angiotensin II receptor blockers in chronic users before noncardiac …