[HTML][HTML] Fixed versus variable dosing of prothrombin complex concentrate for bleeding complications of vitamin K antagonists—the PROPER3 randomized clinical trial
RA Abdoellakhan, N Khorsand, E Ter Avest… - Annals of emergency …, 2022 - Elsevier
Study objective To determine if a fixed dose of 1000 IU of 4-factor prothrombin complex
concentrate (4F-PCC) is as effective as traditional variable dosing based on body weight …
concentrate (4F-PCC) is as effective as traditional variable dosing based on body weight …
Randomised controlled trial protocol to evaluate a fixed dose prothrombin complex concentrate against the variable dose in vitamin K antagonist related bleeding …
RA Abdoellakhan, N Khorsand, RM Van Hest… - BMJ open, 2018 - bmjopen.bmj.com
Introduction There is currently little evidence for the optimal dosing strategy of four-factor
prothrombin complex concentrates (PCC) in vitamin K antagonist (VKA)-related bleeds. The …
prothrombin complex concentrates (PCC) in vitamin K antagonist (VKA)-related bleeds. The …
[HTML][HTML] Clinical outcome of patients with a vitamin K antagonist‐associated bleeding treated with prothrombin complex concentrate
MPA Brekelmans, RA Abdoellakhan… - Research and practice …, 2018 - Elsevier
Essentials• Data on clinical outcome of vitamin K antagonist (VKA)‐associated bleeding is
scarce.• Cohort study of patients with VKA bleeds treated with prothrombin complex …
scarce.• Cohort study of patients with VKA bleeds treated with prothrombin complex …
[HTML][HTML] Method agreement analysis and interobserver reliability of the ISTH proposed definitions for effective hemostasis in management of major bleeding
RA Abdoellakhan, J Beyer‐Westendorf… - Journal of Thrombosis …, 2019 - Elsevier
Essentials• In 2016 the SSC proposed definitions for effective hemostasis in management of
major bleeding.• To validate these definitions, we studied the use in three large …
major bleeding.• To validate these definitions, we studied the use in three large …
Reply: Method agreement analysis and interobserver reliability of the ISTH proposed definitions for effective hemostasis in the management of major bleeding …
RA Abdoellakhan, J Beyer‐Westendorf… - … of Thrombosis and …, 2019 - Wiley Online Library
Discussion on the relevance and importance of this paradox has also been published, 3
addressing the fact that the expected degree of correction for agreement by chance is …
addressing the fact that the expected degree of correction for agreement by chance is …