[HTML][HTML] Adipose tissue aging: mechanisms and therapeutic implications

MY Ou, H Zhang, PC Tan, SB Zhou, QF Li - Cell death & disease, 2022 - nature.com
Adipose tissue, which is the crucial energy reservoir and endocrine organ for the
maintenance of systemic glucose, lipid, and energy homeostasis, undergoes significant …

Association of deprescribing with reduction in mortality and hospitalization: a pragmatic stepped-wedge cluster-randomized controlled trial

CH Kua, CYY Yeo, PC Tan, CWT Char… - Journal of the American …, 2021 - Elsevier
Objectives Deprescribing has gained awareness recently, but the clinical benefits observed
from randomized trials are limited. The aim of this study was to examine the effectiveness of …

[HTML][HTML] The combination of trehalose and glycerol: an effective and non-toxic recipe for cryopreservation of human adipose-derived stem cells

TY Zhang, PC Tan, Y Xie, XJ Zhang, PQ Zhang… - Stem Cell Research & …, 2020 - Springer
Background Adipose-derived stem cells (ADSCs) promote tissue regeneration and repair.
Cryoprotective agents (CPAs) protect cells from cryodamage during cryopreservation. Safe …

[HTML][HTML] The effect of glycerol as a cryoprotective agent in the cryopreservation of adipose tissue

PQ Zhang, PC Tan, YM Gao, XJ Zhang, Y Xie… - Stem Cell Research & …, 2022 - Springer
Background Long-term preservation of adipose tissue is crucial for clinical applications.
Researchers should consider both efficiency and biosafety when choosing a cryoprotective …

[HTML][HTML] Mechanical stretching can modify the papillary dermis pattern and papillary fibroblast characteristics during skin regeneration

PC Tan, SB Zhou, MY Ou, JZ He, PQ Zhang… - Journal of Investigative …, 2022 - Elsevier
Clinical application of mechanical stretching is a reconstructive method for skin repair.
Although studies have reported dermal fibroblast heterogeneity, whether stretching affects …

[HTML][HTML] Dedifferentiated Schwann cell-derived TGF-β3 is essential for the neural system to promote wound healing

MY Ou, PC Tan, Y Xie, K Liu, YM Gao, XS Yang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Wound healing is among the most complicated physiological processes and
requires the synchronization of various cell types with distinct roles to re-establish the …

[HTML][HTML] A randomized, controlled clinical trial of autologous stromal vascular fraction cells transplantation to promote mechanical stretch-induced skin regeneration

PC Tan, PC Chao, C Cheng, CH Chen… - Stem cell research & …, 2021 - Springer
Background The regeneration response of the skin to mechanical stretching in vivo has
been explored in reconstructive surgery to repair large-scale deformities. The ability of the …

Nursing home team-care deprescribing study: a stepped-wedge randomised controlled trial protocol

CH Kua, CYY Yeo, CWT Char, CWY Tan, PC Tan… - BMJ open, 2017 - bmjopen.bmj.com
Introduction An ageing population has become an urgent concern for Asia in recent times. In
nursing homes, polypharmacy has also become a compounding issue. Deprescribing …

Autologous concentrated growth factors combined with topical minoxidil for the treatment of male androgenetic alopecia: a randomized controlled clinical trial

PC Tan, PQ Zhang, Y Xie, YM Gao, QF Li… - Facial Plastic Surgery …, 2021 - liebertpub.com
Background: Minoxidil (MXD) is an US Food and Drug Administration-approved drug for the
topical treatment of androgenetic alopecia (AGA) with minor side effects, but its hair growth …

Identifying characteristics of dermal fibroblasts in skin homeostasis and disease

FZ Chen, PC Tan, Z Yang, Q Li… - Clinical and Experimental …, 2023 - academic.oup.com
Heterogeneous dermal fibroblasts are the main components that constitute the dermis.
Distinct fibroblast subgroups show specific characteristics and functional plasticity that …