Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled …
Summary Background The Xpert MTB/RIF test for tuberculosis is being rolled out in many
countries, but evidence is lacking regarding its implementation outside laboratories, ability to …
countries, but evidence is lacking regarding its implementation outside laboratories, ability to …
Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic …
Background HIV-associated tuberculosis is difficult to diagnose and results in high mortality.
Frequent extra-pulmonary presentation, inability to obtain sputum, and paucibacillary …
Frequent extra-pulmonary presentation, inability to obtain sputum, and paucibacillary …
Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study
Background Rapid and accurate diagnosis of pulmonary tuberculosis in children remains
challenging because of difficulties in obtaining sputum samples and the paucibacillary …
challenging because of difficulties in obtaining sputum samples and the paucibacillary …
Increased and expedited case detection by Xpert MTB/RIF assay in childhood tuberculosis: a prospective cohort study
A Rachow, P Clowes, E Saathoff… - Clinical infectious …, 2012 - academic.oup.com
Background. Diagnosis and timely treatment of tuberculosis in children is hampered by the
absence of fast and reliable tests, especially in the era of human immunodeficiency virus …
absence of fast and reliable tests, especially in the era of human immunodeficiency virus …
Assessment of the novel T-cell activation marker–tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study
D Portevin, F Moukambi, P Clowes, A Bauer… - The Lancet infectious …, 2014 - thelancet.com
Background The diagnosis of paediatric tuberculosis is complicated by non-specific
symptoms, difficult specimen collection, and the paucibacillary nature of the disease. We …
symptoms, difficult specimen collection, and the paucibacillary nature of the disease. We …
[HTML][HTML] Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study
Background The successful cure of tuberculosis (TB) is dependent on adherence to
treatment. Various factors influence adherence, however, few are easily modifiable. There …
treatment. Various factors influence adherence, however, few are easily modifiable. There …
Xpert MTB/RIF Ultra assay for the diagnosis of pulmonary tuberculosis in children: a multicentre comparative accuracy study
Objectives We evaluated the diagnostic performance of the novel next-generation Xpert
MTB/RIF Ultra (Xpert Ultra) in comparison to Xpert MTB/RIF (Xpert) assay for the detection of …
MTB/RIF Ultra (Xpert Ultra) in comparison to Xpert MTB/RIF (Xpert) assay for the detection of …
[HTML][HTML] Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis
Summary Background Xpert MTB/RIF, the most widely used automated nucleic acid
amplification test for tuberculosis, is available in more than 130 countries. Although …
amplification test for tuberculosis, is available in more than 130 countries. Although …
[HTML][HTML] High seroprevalence of Rift Valley fever and evidence for endemic circulation in Mbeya region, Tanzania, in a cross-sectional study
N Heinrich, E Saathoff, N Weller, P Clowes… - PLoS neglected …, 2012 - journals.plos.org
Background The Rift Valley fever virus (RVFV) is an arthropod-borne phlebovirus. RVFV
mostly causes outbreaks among domestic ruminants with a major economic impact. Human …
mostly causes outbreaks among domestic ruminants with a major economic impact. Human …
Evaluation of the Xpert MTB/RIF assay at a tertiary care referral hospital in a setting where tuberculosis and HIV infection are highly endemic
Abstract Background. There were 1.45 million deaths from tuberculosis (TB) in 2011. A
substantial proportion of active pulmonary TB cases in countries where tuberculosis, human …
substantial proportion of active pulmonary TB cases in countries where tuberculosis, human …