Background Antimicrobial stewardship is advocated to improve the quality of antimicrobial
use. We did a systematic review and meta-analysis to assess whether antimicrobial …

Background In several case reports, the occurrence of Achilles tendon rupture has been
attributed to the use of quinolones, but the epidemiologic evidence for this association is …

Objective Fluoroquinolone antibiotics have been associated with tendinitis and tendon
rupture. In this paper we report on the followup of 42 spontaneous reports of fluoroquinolone …

Significant overtreatment with antibiotics for suspected early onset sepsis (EOS) constitutes
a persisting clinical problem, generating unnecessary risks, harms, and costs for many …

Objectives: The number of defined daily doses (DDD) per 100 patient days is often used as
an indicator for the selection pressure exerted by antibiotics in the hospital setting. However …

Aims To study whether there is agreement between cardiovascular drugs presented at
patient interview and pharmacy records in an elderly population. Setting The Rotterdam …

Background To our knowledge, there are no epidemiologic studies on the association
between cognitive impairment and noncompliance with antihypertensive therapy. We …

Background Influenza-related morbidity and mortality have been extensively studied with
hospital and reimbursement data. However, little is known about the effectiveness of the …

Objective: To compare actual antibiotic use to the stratification based on the sepsis
calculator in newborns with suspected early onset sepsis (EOS). To investigate differences …

Background. To prevent inappropriate empiric antibiotic treatment in patients with
bacteremia caused by third-generation cephalosporin (3GC)–resistant Enterobacteriaceae …