The scope and purpose of this work is 2-fold: to synthesize the available evidence and to
translate it into recommendations. This document provides recommendations only when …

The incidence of sepsis is highest in neonates and children, yet the global burden of sepsis
in these age groups has not been assessed. We reviewed available evidence from …

Background Neonates are at major risk of sepsis, but data on neonatal sepsis incidence are
scarce. We aimed to assess the incidence and mortality of neonatal sepsis worldwide …

Background Antimicrobial resistance (AMR) poses a major threat to human health around
the world. Previous publications have estimated the effect of AMR on incidence, deaths …

Background Sepsis is life-threatening organ dysfunction due to a dysregulated host
response to infection. It is considered a major cause of health loss, but data for the global …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Background: The Institute of Medicine calls for the use of clinical guidelines and practice
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …

Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study
2015 (GBD 2015) provides an up-to-date analysis of the burden of diarrhoeal diseases. This …

Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study
(GBD) 2016 provides an up-to-date analysis of the burden of diarrhoea in 195 countries …

The World Health Organization has adopted a resolution on improving the prevention,
diagnosis, and management of sepsis. Millions of lives can be saved if politicians …