Background The optimum blood pressure target in hypertension remains debated,
especially in coronary artery disease, given concerns for reduced myocardial perfusion if …

Background Metformin might reduce insulin requirement and improve glycaemia in patients
with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to …

Background Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous
studies have shown that allopurinol has positive effects on several cardiovascular …

Background Among patients with chronic heart failure, angiotensin-converting–enzyme
(ACE) inhibitors reduce mortality and hospitalization, but the role of a renin inhibitor in such …

Objective To determine whether ciclosporin is superior to prednisolone for the treatment of
pyoderma gangrenosum, a painful, ulcerating skin disease with a poor evidence base for …

Aims Men and women differ in terms of presentation and management in coronary artery
disease (CAD). Whether these differences translate into different clinical outcomes in stable …

Aims Therapy with iv iron in patients with chronic heart failure (CHF) and iron deficiency (ID)
improves symptoms, functional capacity, and quality of life. We sought to investigate whether …

Importance In the era of widespread revascularization and effective antianginals, the
prevalence and prognostic effect of anginal symptoms and myocardial ischemia among …

Background For patients with heart failure, reduced left ventricular ejection fraction and iron
deficiency, intravenous ferric carboxymaltose administration improves quality of life and …

Background Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD).
However, there is little contemporary data regarding HR and the use of HR-lowering …