[PDF][PDF] Tissue-restricted adaptive type 2 immunity is orchestrated by expression of the costimulatory molecule OX40L on group 2 innate lymphoid cells

TYF Halim, BMJ Rana, JA Walker, B Kerscher… - Immunity, 2018 - cell.com
The local regulation of type 2 immunity relies on dialog between the epithelium and the
innate and adaptive immune cells. Here we found that alarmin-induced expression of the co …

An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity

ACH Szeto, ACF Ferreira, J Mannion, PA Clark… - Nature …, 2023 - nature.com
Naive CD4+ T lymphocytes initially undergo antigen-specific activation to promote a broad-
spectrum response before adopting bespoke cytokine expression profiles shaped by …

Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1α to reduce acute lung inflammation and injury in mice

PA Quintero, MD Knolle, LF Cala, Y Zhuang… - The journal of …, 2010 - journals.aai.org
To determine the role of matrix metalloproteinase-8 (MMP-8) in acute lung injury (ALI), we
delivered LPS or bleomycin by the intratracheal route to MMP-8−/− mice versus wild-type …

ADAM8: a new therapeutic target for asthma

MD Knolle, CA Owen - Expert opinion on therapeutic targets, 2009 - Taylor & Francis
Background: A proteinase with a disintegrin and a metalloproteinase domain-8 (ADAM8)
has been linked to asthma. Objective: To explore whether ADAM8 is a therapeutic target for …

Profibrotic activities for matrix metalloproteinase-8 during bleomycin-mediated lung injury

VJ Craig, PA Quintero, SE Fyfe, AS Patel… - The Journal of …, 2013 - journals.aai.org
Abstract Matrix metalloproteinase-8 (MMP-8) is a potent interstitial collagenase thought to be
expressed mainly by polymorphonuclear neutrophils. To determine whether MMP-8 …

Adam8 limits the development of allergic airway inflammation in mice

MD Knolle, T Nakajima, A Hergrueter… - The Journal of …, 2013 - journals.aai.org
To determine whether a disintegrin and metalloproteinase-8 (Adam8) regulates allergic
airway inflammation (AAI) and airway hyperresponsiveness (AHR), we compared AAI and …

[HTML][HTML] MicroRNA-155 protects group 2 innate lymphoid cells from apoptosis to promote type-2 immunity

MD Knolle, SB Chin, BMJ Rana, A Englezakis… - Frontiers in …, 2018 - frontiersin.org
Group-2 innate lymphoid cells (ILC2) play critical roles in the initiation and maintenance of
type-2 immune responses, predominantly through their production of the type-2 cytokines IL …

How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis

NG Cunniffe, SJ Gunter, M Brown, SW Burge… - BMJ open, 2020 - bmjopen.bmj.com
Objectives To analyse enrolment to interventional trials during the first wave of the COVID-
19 pandemic in England and describe the barriers to successful recruitment in the …

IL-25 as a potential therapeutic target in allergic asthma

MD Knolle, BM Rana, ANJ McKenzie - Immunotherapy, 2015 - Future Medicine
Commentary Knolle, Rana & McKenzie for example, administration of IL-25 into mouse
lungs reproduces many features of allergic airway inflammation. Furthermore, neutralization …

Combining clinical, radiological and genetic approaches to pneumothorax management

HL Grimes, S Holden, J Babar, S Karia… - Thorax, 2022 - thorax.bmj.com
Familial spontaneous pneumothorax (FSP) accounts for 10% of primary spontaneous
pneumothoraces. Appropriate investigation of FSP enables early diagnosis of serious …