Gene fusions created by somatic genomic rearrangements are known to play an important
role in the onset and development of some cancers, such as lymphomas and sarcomas …

Motivation: Next-generation sequencing (NGS) has enabled whole genome and
transcriptome single nucleotide variant (SNV) discovery in cancer. NGS produces millions of …

Bacterial and viral pathogens affect their eukaryotic host partly by interacting with proteins of
the host cell. Hence, to investigate infection from a systems' perspective we need to …

Evolution of biological interaction networks: from models to real data | Genome Biology Skip to
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Protein kinases are key regulators of cellular processes. In spite of considerable effort, a full
understanding of the pathways they participate in remains elusive. We globally investigated …

Current combinatorial selection strategies for protein engineering have been successful at
generating binders against a range of targets; however, the combinatorial nature of the …

Hydrophobic cores are often viewed as tightly packed and rigid, but they do show some
plasticity and could thus be attractive targets for protein design. Here we explored the role of …

The analysis of network evolution has been hampered by limited availability of protein
interaction data for different organisms. In this study, we investigate evolutionary …

Protein design remains an important problem in computational structural biology. Current
computational protein design methods largely use physics-based methods, which make use …

Introduction In low-income and middle-income countries, pneumonia remains the leading
cause of illness and death in children< 5 years. The recommended tool for diagnosing …