Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Background Sepsis is a health problem of global importance; treatments focus on controlling
infection and supporting failing organs. Recent clinical research suggests that intravenous …

Usual care control arms may enhance generalizability while introducing significant
limitations. Potential solutions include the use of pretrial surveys to evaluate the extent to …

Background The burden of sepsis is high in India and is associated with substantial
morbidity and mortality. Vitamin C, an endogenous antioxidant, may improve patient …

Purpose Canadian donor management practices have not been reported. Our aim was to
inform clinicians and other stakeholders about the range of current practices. Methods This …

Introduction Observational evidence suggests physiological benefits and lower mortality with
lower chloride solutions; however, 0.9% saline remains the most widely used fluid …

Objectives: Mechanisms underlying sepsis-associated encephalopathy remain unclear, but
reduced cerebral blood flow, alone or in conjunction with altered autoregulation, is reported …

Purpose To categorize, quantify and interpret findings documented in feedback letters of
monitoring or auditing visits for an investigator-initiated, peer-review funded multicenter …

Background The LOVIT (Lessening Organ Dysfunction with Vitamin C) trial is a blinded
multicenter randomized clinical trial comparing high-dose intravenous vitamin C to placebo …

Introduction Research on the management of deceased organ donors aims to improve the
number and quality of transplants and recipient outcomes. In Canada, this research is …