Importance Effective therapies for patients with coronavirus disease 2019 (COVID-19) are
needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced …

Sepsis and multiple organ failure remain leading causes of death in intensive care patients.
Recent advances in our understanding of the pathophysiology of these syndromes include a …

Sepsis is a major cause of mortality and morbidity in intensive care units. Organ dysfunction
is triggered by inflammatory insults and tissue hypoperfusion. The brain plays a pivotal role …

There is no consensual definition of refractory shock. The use of more than 0.5 mcg/kg/min
of norepinephrine or epinephrine to maintain target blood pressure is often used in clinical …

Introduction Residual inflammation at ICU discharge may have impact upon long-term
mortality. However, the significance of ongoing inflammation on mortality after ICU discharge …

Background The sepsis burden on acute care services in middle-income countries is a
cause for concern. We estimated incidence, prevalence, and mortality of sepsis in adult …

Importance The effects of intensive care unit (ICU) visiting hours remain uncertain. Objective
To determine whether a flexible family visitation policy in the ICU reduces the incidence of …

Introduction Sedation overuse is frequent and possibly associated with poor outcomes in the
intensive care unit (ICU) patients. However, the association of early oversedation with …

Introduction Mechanisms underlying inotropic failure in septic shock are incompletely
understood. We previously identified the presence of exosomes in the plasma of septic …

Background Previous studies showed higher sepsis mortality rates in Brazil compared to
other developed or developing countries. Moreover, another trial demonstrated an …