Executive summary Although health outcomes have improved in low-income and middle-
income countries (LMICs) in the past several decades, a new reality is at hand. Changing …

China has made remarkable progress in strengthening its primary health-care system.
Nevertheless, the system still faces challenges in structural characteristics, incentives and …

Objectives: This study sought to investigate the efficacy and safety of clopidogrel in women
and men. Background: Previous analyses have shown sex-based differences in response to …

Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial
infarction, ischaemic stroke, and the need for coronary revascularisation in people without …

Background Tobacco use is one of the major avoidable causes of cardiovascular diseases.
We aimed to assess the risks associated with tobacco use (both smoking and non-smoking) …

Background Hypertension is common in China and its prevalence is rising, yet it remains
inadequately controlled. Few studies have the capacity to characterise the epidemiology …

Background Vorapaxar is a new oral protease-activated–receptor 1 (PAR-1) antagonist that
inhibits thrombin-induced platelet activation. Methods In this multinational, double-blind …

Background Despite the importance of ST-segment elevation myocardial infarction (STEMI)
in China, no nationally representative studies have characterised the clinical profiles …

Nanoscale metal organic frameworks (NMOFs) have shown great potential in biomedicine
owing to their structural/chemical diversities, high molecular loading capacities, and intrinsic …

Job insecurity is one of the most common stressors in contemporary working life. Although
research indicates that the job insecurity construct has cognitive (ie, the perceived negative …