Background The recurrence score based on the 21-gene breast-cancer assay has been
clinically useful in predicting a chemotherapy benefit in hormone-receptor–positive, human …

Background Preferred neoadjuvant regimens for early-stage triple-negative breast cancer
(TNBC) include anthracycline-cyclophosphamide and taxane-based chemotherapy …

Background The safety and short-term efficacy of laparoscopic surgery for rectal cancer after
preoperative chemoradiotherapy has not been demonstrated. The aim of the randomised …

Background Compared with open resection, laparoscopic resection of rectal cancers is
associated with improved short-term outcomes, but high-level evidence showing similar long …

Background An earlier analysis of this phase 3 trial showed that the addition of a cyclin-
dependent kinase 4 and 6 (CDK4/6) inhibitor to endocrine therapy provided a greater …

Background In MONALEESA-2, ribociclib plus letrozole showed improved progression-free
survival compared with letrozole alone as first-line treatment for postmenopausal patients …

Background Most patients with ovarian cancer will relapse after receiving frontline platinum-
based chemotherapy and eventually develop platinum-resistant or platinum-refractory …

Background The role of adjuvant chemotherapy for patients with rectal cancer is
controversial, especially when used after preoperative chemoradiotherapy. Fluoropyrimidine …

Background HER2-targeted treatments have improved outcomes in patients with HER2-
positive breast cancer in the neoadjuvant, adjuvant, and metastatic settings; however, some …

Improving the prognosis for patients with metastatic HR+/HER2-breast cancer remains an
unmet need. Patients with tumors that have progressed on endocrine therapy and/or are not …