User profiles for "author:Kyra Chua"

Kyra Chua

Austin Health
Verified email at austin.org.au
Cited by 2905

Antimicrobial resistance: Not community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)! A clinician's guide to community MRSA-its evolving …

K Chua, F Laurent, G Coombs, ML Grayson… - … diseases: an official …, 2011 - europepmc.org
A comment on this article appears in" Treatment of skin and soft tissue infections due to
community-associated methicillin-resistant Staphylococcus aureus in Europe: the role of …

[HTML][HTML] Evolution of Multidrug Resistance during Staphylococcus aureus Infection Involves Mutation of the Essential Two Component Regulator WalKR

BP Howden, CRE McEvoy, DL Allen, K Chua… - PLoS …, 2011 - journals.plos.org
Antimicrobial resistance in Staphylococcus aureus is a major public health threat,
compounded by emergence of strains with resistance to vancomycin and daptomycin, both …

Population genetics and the evolution of virulence in Staphylococcus aureus

KYL Chua, BP Howden, JH Jiang, T Stinear… - Infection, Genetics and …, 2014 - Elsevier
Staphylococcus aureus is one of the most important human pathogens, causing life-
threatening infection in the community and hospital setting. The population genetics of S …

Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis

JYH Lee, IR Monk, A Gonçalves da Silva… - Nature …, 2018 - nature.com
Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely
present on healthy skin. Here we show that S. epidermidis has also evolved to become a …

[HTML][HTML] Two Novel Point Mutations in Clinical Staphylococcus aureus Reduce Linezolid Susceptibility and Switch on the Stringent Response to Promote Persistent …

W Gao, K Chua, JK Davies, HJ Newton… - PLoS …, 2010 - journals.plos.org
Staphylococcus aureus frequently invades the human bloodstream, leading to life
threatening bacteremia and often secondary foci of infection. Failure of antibiotic therapy to …

Development and validation of a penicillin allergy clinical decision rule

JA Trubiano, S Vogrin, KYL Chua, J Bourke… - JAMA internal …, 2020 - jamanetwork.com
Importance Penicillin allergy is a significant public health issue for patients, antimicrobial
stewardship programs, and health services. Validated clinical decision rules are urgently …

The penicillin allergy delabeling program: a multicenter whole-of-hospital health services intervention and comparative effectiveness study

KYL Chua, S Vogrin, S Bury, A Douglas… - Clinical infectious …, 2021 - academic.oup.com
Background Penicillin allergies are associated with inferior patient and antimicrobial
stewardship outcomes. We implemented a whole-of-hospital program to assess the efficacy …

Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk penicillin allergy: the PALACE randomized clinical trial

AM Copaescu, S Vogrin, F James… - JAMA internal …, 2023 - jamanetwork.com
Importance Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The
standard of care to remove the penicillin allergy label in adults is specialized testing …

Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and …

R Rajasuriar, D Booth, A Solomon… - The Journal of …, 2010 - academic.oup.com
Background. Multiple host factors may influence CD4+ T cell reconstitution in human
immunodeficiency virus (HIV)-infected patients after suppressive antiretroviral therapy …

[HTML][HTML] SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

W Zhang, BY Chua, KJ Selva, L Kedzierski… - Nature …, 2022 - nature.com
Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …