Stem cell therapy holds great promise in medicine, but clinical development should be
based on a sound understanding of potential weaknesses in supporting experimental data …

Introduction Dementia poses a considerable socioeconomic burden to society. On a global
scale, family and other unpaid care predominates. Supporting caregivers is crucial, but …

Pain can significantly decrease the quality of life of patients with advanced cancer. Current
treatment strategies often provide inadequate analgesia and unacceptable side effects …

Background. The efficacy of antiretrovirals as postexposure prophylaxis (PEP) to prevent
viral acquisition was demonstrated in nonhuman primate models of human …

In recent years, strong evidence has emerged suggesting that insufficient duration, quality,
and/or timing of sleep are associated with cardiovascular disease (CVD), and various …

Objective To develop and implement an evidence based framework to select, from drugs
already licenced, candidate oral neuroprotective drugs to be tested in secondary …

Background. Regular exercise reduces the risk of a first-ever stroke and is associated with
smaller infarcts. Although evidence has suggested that therapeutic exercise following stroke …

The well-established negative health outcomes of sleep deprivation, and the suggestion that
availability of electricity may enable later bed times without compensating sleep extension in …

BACKGROUND: Parkinson's disease (PD) can be a severely disabling condition in spite of
therapies currently available. Systematic review and meta-analysis can provide an overview …

Purpose Cardiovascular disease (CVD) is a major challenge to global health. The same
epidemiological transition scenario is replayed as countries develop, but with variations …