Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies
Objectives Designing studies with an internal pilot phase may optimise the use of pilot work
to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed …
to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed …
[HTML][HTML] A systematic review of core outcome set development studies demonstrates difficulties in defining unique outcomes
Objectives Core outcome set (COS) development often begins with a systematic review to
identify outcomes. Reviews frequently show heterogeneity in numbers of outcomes reported …
identify outcomes. Reviews frequently show heterogeneity in numbers of outcomes reported …
Health‐related quality of life among patients cured by surgery for esophageal cancer
P Lagergren, KNL Avery, R Hughes… - … Journal of the …, 2007 - Wiley Online Library
BACKGROUND. Little is known regarding the long‐term, health‐related quality of life
(HRQL) of survivors of esophagectomy for cancer. METHODS. Consecutive patients …
(HRQL) of survivors of esophagectomy for cancer. METHODS. Consecutive patients …
Behavior theory for dietary interventions for cancer prevention: a systematic review of utilization and effectiveness in creating behavior change
Purpose Theory-based approaches are now recommended to design and enact dietary
interventions, but their use in cancer trials is unknown. This systematic review examined …
interventions, but their use in cancer trials is unknown. This systematic review examined …
Patient-reported outcomes 12 years after localized prostate cancer treatment
JL Donovan, FC Hamdy, JA Lane, GJ Young… - NEJM …, 2023 - evidence.nejm.org
Background Long-term patient-reported outcomes are needed to inform treatment decisions
for localized prostate cancer. Methods Patient-reported outcomes of 1643 randomly …
for localized prostate cancer. Methods Patient-reported outcomes of 1643 randomly …
Psychometric evaluation of a new patient-completed questionnaire for evaluating anal incontinence symptoms and impact on quality of life: the ICIQ-B
BACKGROUND: A psychometrically robust patient-completed questionnaire for anal
incontinence, which reflects issues of importance to both clinicians and patients, was lacking …
incontinence, which reflects issues of importance to both clinicians and patients, was lacking …
[HTML][HTML] Core outcomes for colorectal cancer surgery: a consensus study
AGK McNair, RN Whistance, RO Forsythe… - PLoS …, 2016 - journals.plos.org
Background Colorectal cancer (CRC) is a major cause of worldwide morbidity and mortality.
Surgical treatment is common, and there is a great need to improve the delivery of such …
Surgical treatment is common, and there is a great need to improve the delivery of such …
Psychological impact of prostate biopsy: physical symptoms, anxiety, and depression
J Wade, DJ Rosario, RC Macefield… - Journal of Clinical …, 2013 - ascopubs.org
Purpose To investigate the psychological impact of prostate biopsy, including relationships
between physical biopsy-related symptoms and anxiety and depression. Patients and …
between physical biopsy-related symptoms and anxiety and depression. Patients and …
Prognostic value of changes in health-related quality of life scores during curative treatment for esophagogastric cancer
T Djärv, C Metcalfe, KNL Avery, P Lagergren… - Journal of Clinical …, 2010 - ascopubs.org
Purpose Accumulating evidence suggests that health-related quality of life (HRQL) data
before treatment predict survival, but the prognostic value of changes in HRQL scores after …
before treatment predict survival, but the prognostic value of changes in HRQL scores after …
[HTML][HTML] The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation
Objective To evaluate the impact of the QuinteT Recruitment Intervention (QRI) on
recruitment in challenging randomized controlled trials (RCTs) that have applied the …
recruitment in challenging randomized controlled trials (RCTs) that have applied the …