1. Background: Recent medical advancements, and improvements in hygiene and food
supply have led to Japan having the longest life expectancy in the world. Over the past 50 …

Abstract Aim In 2005, the Japan Geriatrics Society published a list of potentially
inappropriate medication that was an extract from the “Guidelines for medical treatment and …

Background: Cerebral small vessel diseases, including silent lacunar infarcts, white matter
hyperintensities, and microbleeds, pose a risk for cerebrovascular disease, cognitive …

Background Estrogen has been reported to augment endothelium-dependent
vasodilatation. The role of endogenous ovarian hormones in modulating endothelium …

Importance Blood-based tests for brain amyloid-β (Aβ) pathology are needed for widespread
implementation of Alzheimer disease (AD) biomarkers in clinical care and to facilitate patient …

Aim The K ihon Checklist is extensively used in J apan to identify elderly persons who are at
risk of requiring support/care. We aimed to determine whether or not the K ihon Checklist …

Background The demographic structure of a country changes dramatically with increasing
trends toward general population aging and declining birth rates. In J apan, the percentage …

1Federation of National Public Service Personnel Mutual Aid Associations Toranomon
Hospital, Tokyo, Japan 2Department of Geriatric and General Medicine, Osaka University …

Flow-mediated dilation (FMD) of the brachial artery, carotid intima-media thickness (IMT)
and pulse wave velocity (PWV) have been shown to be good surrogate markers of clinical …

The effectiveness and safety of yokukansan (TJ-54), a traditional Japanese medicine
(kampo) for the treatment of the behavioural and psychological symptoms of dementia …