User profiles for "author:Jonathan Kimmelman"

Jonathan Kimmelman

Biomedical Ethics, McGill University
Verified email at mcgill.ca
Cited by 8957

[PDF][PDF] ISSCR guidelines for stem cell research and clinical translation: the 2021 update

R Lovell-Badge, E Anthony, RA Barker, T Bubela… - Stem cell reports, 2021 - cell.com
Summary The International Society for Stem Cell Research has updated its Guidelines for
Stem Cell Research and Clinical Translation in order to address advances in stem cell …

[HTML][HTML] Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments

VC Henderson, J Kimmelman, D Fergusson… - PLoS …, 2013 - journals.plos.org
Background The vast majority of medical interventions introduced into clinical development
prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed …

Increasing placebo responses over time in US clinical trials of neuropathic pain

AH Tuttle, S Tohyama, T Ramsay, J Kimmelman… - Pain, 2015 - journals.lww.com
Recent failures of clinical trials of novel analgesics designed to treat neuropathic pain have
led to much speculation about the underlying reasons. One often discussed possibility is that …

Sunburn and p53 in the onset of skin cancer

A Ziegler, AS Jonason, DJ Leffellt, JA Simon… - Nature, 1994 - nature.com
SQUAMOUS cell carcinoma of the skin (SCC) can progress by stages: sun-damaged
epidermis, with individual disordered keratin-ocytes; actinic keratosis (AK), spontaneously …

Against pandemic research exceptionalism

AJ London, J Kimmelman - Science, 2020 - science.org
The global outbreak of coronavirus disease 2019 (COVID-19) has seen a deluge of clinical
studies, with hundreds registered on clinicaltrials. gov. But a palpable sense of urgency and …

Unsuccessful trial accrual and human subjects protections: an empirical analysis of recently closed trials

B Carlisle, J Kimmelman, T Ramsay… - Clinical …, 2015 - journals.sagepub.com
Background Ethical evaluation of risk–benefit in clinical trials is premised on the
achievability of resolving research questions motivating an investigation. Objective To …

[HTML][HTML] Distinguishing between exploratory and confirmatory preclinical research will improve translation

J Kimmelman, JS Mogil, U Dirnagl - PLoS biology, 2014 - journals.plos.org
Preclinical researchers confront two overarching agendas related to drug development:
selecting interventions amid a vast field of candidates, and producing rigorous evidence of …

[PDF][PDF] Setting global standards for stem cell research and clinical translation: the 2016 ISSCR guidelines

GQ Daley, I Hyun, JF Apperley, RA Barker… - Stem cell reports, 2016 - cell.com
The International Society for Stem Cell Research (ISSCR) presents its 2016 Guidelines for
Stem Cell Research and Clinical Translation (ISSCR, 2016). The 2016 guidelines reflect the …

The effect of overdose education and naloxone distribution: an umbrella review of systematic reviews

A Razaghizad, SB Windle, KB Filion… - … journal of public …, 2021 - ajph.aphapublications.org
Background. Opioids contribute to more than 60 000 deaths annually in North America.
While the expansion of overdose education and naloxone distribution (OEND) programs has …

Ethics of controlled human infection to address COVID-19

SK Shah, FG Miller, TC Darton, D Duenas, C Emerson… - Science, 2020 - science.org
Development of an effective vaccine is the clearest path to controlling the coronavirus
disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some …