User profiles for "author:Jonathan Kimmelman"
Jonathan KimmelmanBiomedical Ethics, McGill University Verified email at mcgill.ca Cited by 8957 |
[PDF][PDF] ISSCR guidelines for stem cell research and clinical translation: the 2021 update
R Lovell-Badge, E Anthony, RA Barker, T Bubela… - Stem cell reports, 2021 - cell.com
Summary The International Society for Stem Cell Research has updated its Guidelines for
Stem Cell Research and Clinical Translation in order to address advances in stem cell …
Stem Cell Research and Clinical Translation in order to address advances in stem cell …
[HTML][HTML] Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments
VC Henderson, J Kimmelman, D Fergusson… - PLoS …, 2013 - journals.plos.org
Background The vast majority of medical interventions introduced into clinical development
prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed …
prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed …
Increasing placebo responses over time in US clinical trials of neuropathic pain
Recent failures of clinical trials of novel analgesics designed to treat neuropathic pain have
led to much speculation about the underlying reasons. One often discussed possibility is that …
led to much speculation about the underlying reasons. One often discussed possibility is that …
Sunburn and p53 in the onset of skin cancer
A Ziegler, AS Jonason, DJ Leffellt, JA Simon… - Nature, 1994 - nature.com
SQUAMOUS cell carcinoma of the skin (SCC) can progress by stages: sun-damaged
epidermis, with individual disordered keratin-ocytes; actinic keratosis (AK), spontaneously …
epidermis, with individual disordered keratin-ocytes; actinic keratosis (AK), spontaneously …
Against pandemic research exceptionalism
AJ London, J Kimmelman - Science, 2020 - science.org
The global outbreak of coronavirus disease 2019 (COVID-19) has seen a deluge of clinical
studies, with hundreds registered on clinicaltrials. gov. But a palpable sense of urgency and …
studies, with hundreds registered on clinicaltrials. gov. But a palpable sense of urgency and …
Unsuccessful trial accrual and human subjects protections: an empirical analysis of recently closed trials
B Carlisle, J Kimmelman, T Ramsay… - Clinical …, 2015 - journals.sagepub.com
Background Ethical evaluation of risk–benefit in clinical trials is premised on the
achievability of resolving research questions motivating an investigation. Objective To …
achievability of resolving research questions motivating an investigation. Objective To …
[HTML][HTML] Distinguishing between exploratory and confirmatory preclinical research will improve translation
Preclinical researchers confront two overarching agendas related to drug development:
selecting interventions amid a vast field of candidates, and producing rigorous evidence of …
selecting interventions amid a vast field of candidates, and producing rigorous evidence of …
[PDF][PDF] Setting global standards for stem cell research and clinical translation: the 2016 ISSCR guidelines
The International Society for Stem Cell Research (ISSCR) presents its 2016 Guidelines for
Stem Cell Research and Clinical Translation (ISSCR, 2016). The 2016 guidelines reflect the …
Stem Cell Research and Clinical Translation (ISSCR, 2016). The 2016 guidelines reflect the …
The effect of overdose education and naloxone distribution: an umbrella review of systematic reviews
A Razaghizad, SB Windle, KB Filion… - … journal of public …, 2021 - ajph.aphapublications.org
Background. Opioids contribute to more than 60 000 deaths annually in North America.
While the expansion of overdose education and naloxone distribution (OEND) programs has …
While the expansion of overdose education and naloxone distribution (OEND) programs has …
Ethics of controlled human infection to address COVID-19
Development of an effective vaccine is the clearest path to controlling the coronavirus
disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some …
disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some …