Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for …

In contrast to a detailed understanding of antiviral cellular immune responses, the impact of
neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis …

Background—The Framingham Coronary Heart Disease (CHD) prediction score is
recommended for global risk assessment in subjects prone to CHD. Recently, C-reactive …

Background—C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals
with myocardial infarction and 1,298 controls, in silico replication in three additional genome …

Background—Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory
response in the arterial vessel wall. Methods and Results—In a prospective, nested, case …

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …

Genome-wide association studies (GWASs) have identified many SNPs underlying
variations in plasma-lipid levels. We explore whether additional loci associated with plasma …

Objective—The purpose of this study was to assess whether increasing serum uric acid (UA)
levels are related to cardiovascular disease (CVD) mortality, all-cause mortality, and incident …

OBJECTIVE: It has been suggested that low-grade systemic inflammation is associated with
obesity and that this association might be modified by sex. METHODS AND RESULTS: We …