Lithium use in mental diseases has changed over the years but remains a cornerstone of
treatment in bipolar disorders. In two companion papers, we have reviewed existing (and …

After a single dose, lithium, usually given as carbonate, reaches a peak plasma
concentration at 1.0–2.0 hours for standard-release dosage forms, and 4–5 hours for …

BACKGROUND: To evaluate the efficacy of psychoeducation in the treatment of bipolar
disorder according to specific therapeutic targets such as treatment compliance, patients' …

Recent findings with animal models have suggested a possible role for brain-derived
neurotrophic factor (BDNF) in depression. We have therefore hypothesized that depression …

Corticotropin releasing factor (CRF) is a major integrator of adaptive responses to stress.
Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and …

BACKGROUND: Recent reports have suggested a role for brain-derived neurotrophic factor
(BDNF) in psychiatric disorders. Decreased serum BDNF levels have been reported in major …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However …

BACKGROUND: Mindfulness-Based Cognitive Therapy (MBCT) is a group intervention that
integrates elements of Cognitive Behavioural Therapy (CBT) with components of …

We had previously reported decreased serum brain-derived neurotrophic factor (BDNF)
levels in depressed patients. In the present study, we tested the hypothesis that …

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have …