Sepsis is a common cause of death, but outcomes in individual patients are difficult to
predict. Elucidating the molecular processes that differ between sepsis patients who survive …

Metabolic profiling of cancer cells has recently been established as a promising tool for the
development of therapies and identification of cancer biomarkers. Here we characterized the …

Background. A novel translational pharmacology investigation was conducted by combining
an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical …

Global metabolic profiling currently achievable by untargeted mass spectrometry-based
metabolomic platforms has great potential to advance our understanding of human disease …

Precision medicine, taking account of human individuality in genes, environment, and
lifestyle for early disease diagnosis and individualized therapy, has shown great promise to …

Background The application of whole-exome sequencing for the diagnosis of genetic
disease has paved the way for systems-based approaches in the clinical laboratory. Here …

Bladder cancer (BCa) is a common malignancy worldwide and has a high probability of
recurrence after initial diagnosis and treatment. As a result, recurrent surveillance, primarily …

Drug-induced liver injury (DILI) is a significant consideration for drug development. Current
preclinical DILI assessment relying on histopathology and clinical chemistry has limitations …

Bovine milk contains a complex mixture of metabolites, which were identified by liquid and
gas chromatography mass spectrometry methods. With the aid of new software methods …

Our objective was to identify plasma biomarkers of ALS that can aid in distinguishing
patients with ALS from those with disease mimics. In this multi-center study, plasma samples …