Importance Cannabis and cannabinoid drugs are widely used to treat disease or alleviate
symptoms, but their efficacy for specific indications is not clear. Objective To conduct a …

Objective To develop ROBIS, a new tool for assessing the risk of bias in systematic reviews
(rather than in primary studies). Study Design and Setting We used four-stage approach to …

Objectives To assess the association between infant size or growth and subsequent obesity
and to determine if any association has been stable over time. Design Systematic review …

Systematic reviews and meta-analyses are essential to summarize evidence relating to
efficacy and safety of health care interventions accurately and reliably. The clarity and …

Background In the era of evidence based medicine, with systematic reviews as its
cornerstone, adequate quality assessment tools should be available. There is currently a …

Clinical prediction models combine multiple predictors to estimate risk for the presence of a
particular condition (diagnostic models) or the occurrence of a certain event in the future …

Background: Alterations in waveforms in the uterine artery are associated with the
development of pre-eclampsia and intrauterine growth restriction. We investigated the …

Systematic reviews and meta-analyses are a key element of evidence-based healthcare, yet
they remain in some ways mysterious. Why did the authors select certain studies and reject …

Background Throughout history, doctor-patient relationships have been acknowledged as
having an important therapeutic effect, irrespective of any prescribed drug or treatment. We …

Background: Studies of diagnostic accuracy are subject to different sources of bias and
variation than studies that evaluate the effectiveness of an intervention. Little is known about …