Research over the past decade has revealed the increasingly complex biologic features of
the CD4+ T-cell lineage. This T-cell subset, which was originally defined on the basis of …

Colorectal cancer (CRC) is the third most common malignancy in the world. Because CRC
develops slowly from removable precancerous lesions, detection of the disease at an early …

Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell
cycle and are required for the initiation and progression of various malignancies …

Mounting an efficient immune response to pathogens while avoiding damage to host tissues
is the central task of the immune system. Emerging evidence has highlighted the …

Invariant natural killer T cells (iNKT cells) have an innate immunity–like rapidity of response
and the ability to modulate the effector functions of other cells. We show here that iNKT cells …

T helper type 17 (TH17) cells are highly proinflammatory effector T cells that are
characterized by the production of high amounts of IL-17A, IL-17F, IL-21, and IL-22 …

Abstract Objective FTY720, a sphingosine‐1‐phosphate (S1P) receptor agonist that crosses
the blood–brain barrier, is a potential immuno‐therapy for multiple sclerosis. Our objective …

PARP inhibitors have shown promising clinical activities for patients with BRCA mutations
and are changing the landscape of ovarian cancer treatment. However, the therapeutic …

The ability to produce vigorous immune responses that spare self tissues and organs
depends on the elimination of autoreactive T and B cells. However, purging of immature and …

The maintenance of immune homeostasis requires regulatory T cells (Tregs). Given their
intrinsic self-reactivity, Tregs must stably maintain a suppressive phenotype to avoid …