Background: The COVID-19 pandemic has caused considerable morbidity, mortality and
disruption to people's lives around the world. There are concerns that rates of suicide and …

Background Surgical site infection (SSI) rates vary from 1% to 5% in the month following
surgery. Due to the large number of surgical procedures conducted annually, the costs of …

Assessment of risk of bias is regarded as an essential component of a systematic review on
the effects of an intervention. The most commonly used tool for randomised trials is the …

Oral bioavailability measurements in rats for over 1100 drug candidates studied at
SmithKline Beecham Pharmaceuticals (now GlaxoSmithKline) have allowed us to analyze …

Objective To determine the most effective interventions in recently detoxified, alcohol
dependent patients for implementation in primary care. Design Systematic review and …

The antioxidant effect of carvedilol, a new vasodilating, beta adrenoceptor blocker was
studied and compared with five other beta blockers. Carvedilol rapidly inhibited Fe (++) …

The hepatitis C virus (HCV) NS5B protein encodes an RNA-dependent RNA polymerase
(RdRp), the primary catalytic enzyme of the HCV replicase complex. We established a …

Tibetan natives have lived on the Tibetan plateau (altitude∼ 4,000 m) for at least 25,000
years, and as such they are adapted to life and reproduction in a hypoxic environment …

Modification of the pyrimidone 5-substituent in clinical candidate SB-435495 has given a
series of inhibitors of recombinant lipoprotein-associated phospholipase A2 with sub …

BACKGROUND. Iron bioavailability has been identified as a factor that influences cellular
hypoxia sensing, putatively via an action on the hypoxia-inducible factor (HIF) pathway. We …