Prostate cancer is a common malignancy in men and the worldwide burden of this disease
is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control …

CONTEXT: MicroRNAs (miRNA) are noncoding RNAs that post-transcriptionally regulate
gene expression. Their altered expression and function have been observed in most …

OBJECTIVE:: Measurement of serum prostate-specific antigen (PSA) for the detection of
prostate cancer has poor specificity in men with PSA levels between 2 and 10ng/ml. It has …

Background The comparative effectiveness of treatments for prostate cancer that is detected
by prostate-specific antigen (PSA) testing remains uncertain. Methods We compared active …

Background Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 and
69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer …

Background Robust data on patient-reported outcome measures comparing treatments for
clinically localized prostate cancer are lacking. We investigated the effects of active …

Prostate cancer is the most common cancer affecting males in developed countries. It shows
consistent evidence of familial aggregation, but the causes of this aggregation are mostly …

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To
identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a …

Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …