Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double …

TX Zhao, M Kostapanos, C Griffiths, EL Arbon… - BMJ open, 2018 - bmjopen.bmj.com
Introduction Inflammation and dysregulated immune responses play a crucial role in
atherosclerosis, underlying ischaemic heart disease (IHD) and acute coronary syndromes …

Regulatory T-cell response to low-dose interleukin-2 in ischemic heart disease

TX Zhao, RS Sriranjan, ZK Tuong, Y Lu… - NEJM …, 2022 - evidence.nejm.org
Background Atherosclerosis is a chronic inflammatory disease of the artery wall. Regulatory
T cells (Tregs) limit inflammation and promote tissue healing. Low doses of interleukin (IL)-2 …

[HTML][HTML] A pragmatic, open-label, randomized controlled trial of Plasma-Lyte-148 versus standard intravenous fluids in children receiving kidney transplants (PLUTO)

WN Hayes, E Laing, R Brown, L Silsby, L Smith… - Kidney International, 2024 - Elsevier
Acute electrolyte and acid-base imbalance is experienced by many children following
kidney transplant. This is partly because doctors give very large volumes of artificial fluids to …

Convalescent plasma donors show enhanced cross‐reactive neutralizing antibody response to antigenic variants of SARS‐CoV‐2 following immunization

H Harvala, D Nguyen, P Simmonds… - …, 2022 - Wiley Online Library
Background The therapeutic benefit of convalescent plasma (CP) therapy to treat COVID‐19
may derive from neutralizing antibodies (nAbs) to SARS‐CoV‐2. To investigate the effects of …

Investigating the Lowest Threshold of Vascular Benefits from LDL Cholesterol Lowering with a PCSK9 mAb Inhibitor (Alirocumab) in Patients with Stable …

PJ Cacciottolo, MS Kostapanos, EH Sancho… - BMJ open, 2021 - bmjopen.bmj.com
Introduction Elevated low-density lipoprotein cholesterol (LDL-C) is a strong independent
risk predictor of cardiovascular (CV) events, while interventions to reduce it remain the only …

ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers: A structured …

CM McEniery, M Fisk, K Miles, F Kaloyirou, A Hubsch… - Trials, 2020 - Springer
Abstract Objectives Primary objective To determine whether chemoprophylaxis with
hydroxychloroquine versus placebo increases time to contracting coronavirus disease 2019 …

THE EFFECTS OF ALIROCUMAB VERSUS EZETIMIBE ON TOP OF STATINS ON VASCULAR INFLAMMATION AND FUNCTION

PJ Cacciottolo, M Kostapanos, A Hubsch… - Journal of the American …, 2021 - jacc.org
Background Low-density lipoprotein cholesterol (LDL) is a strong independent risk predictor
of cardiovascular (CV) events. The lowest threshold beyond which reduction of LDL confers …

[PDF][PDF] LETTER Open Access

CM McEniery, M Fisk, K Miles, F Kaloyirou… - 2020 - trialsjournal.biomedcentral.com
ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC)
to prevent covid-19 infection in frontline h Page 1 LETTER Open Access …

Correction to: ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers …

CM McEniery, M Fisk, K Miles, F Kaloyirou, A Hubsch… - Trials, 2020 - ncbi.nlm.nih.gov
Reference 1. McEniery, et al. ChemoPROphyLaxIs with hydroxychloroquine For covId-19
infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers …

CORRECTION Open Access

CM McEniery, M Fisk, K Miles, F Kaloyirou, A Hubsch… - trialsjournal.biomedcentral.com
Reference 1. McEniery, et al. ChemoPROphyLaxIs with hydroxychloroquine For covId-19
infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers …