Purpose MRI is integral to the diagnosis of multiple sclerosis (MS) and is important for
clinical prognostication. Quantitative volumetric reporting tools (QReports) can improve the …

Background Neurodegeneration is the pathological substrate that causes major disability in
secondary progressive multiple sclerosis. A synthesis of preclinical and clinical research …

In established multiple sclerosis, tissue abnormality—as assessed using magnetization
transfer ratio—increases close to the lateral ventricles. We aimed to determine whether or …

Background and Objectives Relapsing-remitting multiple sclerosis (RRMS), aquaporin-4
antibody–positive neuromyelitis optica spectrum disorder (AQP4-NMOSD), and myelin …

Background and Objective To explore the relationship between slowly expanding lesions
(SELs) on MRI and disability in secondary progressive multiple sclerosis (SPMS). Methods …

Introduction The major unmet need in multiple sclerosis (MS) is for neuroprotective therapies
that can slow (or ideally stop) the rate of disease progression. The UK MS Society Clinical …

Background 1H‐magnetic resonance spectroscopy (1H‐MRS) may provide a direct index for
the testing of medicines for neuroprotection and drug mechanisms in multiple sclerosis (MS) …

Background Optic neuropathy is a near ubiquitous feature of Friedreich's ataxia (FRDA).
Previous studies have examined varying aspects of the anterior and posterior visual …

Background: In relapse-onset multiple sclerosis (MS), tissue abnormality–as assessed with
magnetisation transfer ratio (MTR) imaging–is greater in the outer cortical and inner …

Background: In multiple sclerosis (MS), disease effects on magnetisation transfer ratio (MTR)
increase towards the ventricles. This periventricular gradient is evident shortly after first …