Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

J Villar, C Ferrando, D Martínez, A Ambrós… - The Lancet …, 2020 - thelancet.com
Background There is no proven specific pharmacological treatment for patients with the
acute respiratory distress syndrome (ARDS). The efficacy of corticosteroids in ARDS …

Assessment of PaO2/FiO2 for stratification of patients with moderate and severe acute respiratory distress syndrome

J Villar, J Blanco, R del Campo, D Andaluz-Ojeda… - BMJ open, 2015 - bmjopen.bmj.com
Objectives A recent update of the definition of acute respiratory distress syndrome (ARDS)
proposed an empirical classification based on ratio of arterial partial pressure of oxygen to …

A quantile analysis of plateau and driving pressures: effects on mortality in patients with acute respiratory distress syndrome receiving lung-protective ventilation

J Villar, C Martín-Rodríguez… - Critical care …, 2017 - journals.lww.com
Objectives: The driving pressure (plateau pressure minus positive end-expiratory pressure)
has been suggested as the major determinant for the beneficial effects of lung-protective …

[HTML][HTML] Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial

RM Kacmarek, J Villar, D Parrilla, F Alba… - Intensive Care …, 2020 - Springer
Purpose We hypothesized that neurally adjusted ventilatory assist (NAVA) compared to
conventional lung-protective mechanical ventilation (MV) decreases duration of MV and …

[HTML][HTML] Clinical and biological markers for predicting ARDS and outcome in septic patients

J Villar, R Herrán-Monge, E González-Higueras… - Scientific Reports, 2021 - nature.com
Sepsis is a common cause of acute respiratory distress syndrome (ARDS) associated with a
high mortality. A panel of biomarkers (BMs) to identify septic patients at risk for developing …

[HTML][HTML] Whole-blood mitochondrial DNA copies are associated with the prognosis of acute respiratory distress syndrome after sepsis

T Hernández-Beeftink, B Guillen-Guio… - Frontiers in …, 2021 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is an inflammatory process of the lungs that
develops primarily in response to pulmonary or systemic sepsis, resulting in a …

[HTML][HTML] Respiratory Subsets in Patients with Moderate to Severe Acute Respiratory Distress Syndrome for Early Prediction of Death

J Villar, C Fernández, JM González-Martín… - Journal of Clinical …, 2022 - mdpi.com
Introduction: In patients with acute respiratory distress syndrome (ARDS), the PaO2/FiO2
ratio at the time of ARDS diagnosis is weakly associated with mortality. We hypothesized …

A prognostic enrichment strategy for selection of patients with acute respiratory distress syndrome in clinical trials

J Villar, A Ambrós, F Mosteiro, D Martínez… - Critical Care …, 2019 - journals.lww.com
Objectives: Incomplete or ambiguous evidence for identifying high-risk patients with acute
respiratory distress syndrome for enrollment into randomized controlled trials has come at …

[HTML][HTML] Predicting the length of mechanical ventilation in acute respiratory disease syndrome using machine learning: The PIONEER Study

J Villar, JM González-Martín, C Fernández… - Journal of Clinical …, 2024 - mdpi.com
Background: The ability to predict a long duration of mechanical ventilation (MV) by
clinicians is very limited. We assessed the value of machine learning (ML) for early …

[HTML][HTML] A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome

N Hernandez-Pacheco, B Guillen-Guio… - Intensive care medicine …, 2018 - Springer
Background The acute respiratory distress syndrome (ARDS) is one of the main causes of
mortality in adults admitted to intensive care units. Previous studies have demonstrated the …