GTPases are conserved molecular switches, built according to a common structural design.
Rapidly accruing knowledge of individual GTPases—crystal structures, biochemical …

Proteins that bind and hydrolyse GTP are being discovered at a rapidly increasing rate.
Each of these many GTPases acts as a molecular switch whose'on'and'off states are …

A decade ago celiac disease was considered extremely rare outside Europe and, therefore,
was almost completely ignored by health care professionals. In only 10 years, key …

Objective The literature suggests a lack of consensus on the use of terms related to coeliac
disease (CD) and gluten. Design A multidisciplinary task force of 16 physicians from seven …

We explore the simple inter-relationships between mass, star formation rate, and
environment in the SDSS, zCOSMOS, and other deep surveys. We take a purely empirical …

Background The hemoglobin threshold at which postoperative red-cell transfusion is
warranted is controversial. We conducted a randomized trial to determine whether a higher …

A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries
(Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the …

The roots of a dysfunctional health system and the collision of the epidemics of
communicable and non-communicable diseases in South Africa can be found in policies …

Over the past three decades, polymeric gas separation membranes have become widely
used for a variety of industrial gas separations applications. This review presents the …

We present photometric observations of an apparent Type Ia supernova (SN Ia) at a redshift
of∼ 1.7, the farthest SN observed to date. The supernova, SN 1997ff, was discovered in a …