[HTML][HTML] Criteria for pediatric sepsis—a systematic review and meta-analysis by the pediatric sepsis definition taskforce
Objective: To determine the associations of demographic, clinical, laboratory, organ
dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic …
dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic …
[HTML][HTML] Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …
(including infants, school-aged children, and adolescents) with septic shock and other …
[HTML][HTML] Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a …
P Davies, C Evans, HK Kanthimathinathan… - The Lancet Child & …, 2020 - thelancet.com
Summary Background In April, 2020, clinicians in the UK observed a cluster of children with
unexplained inflammation requiring admission to paediatric intensive care units (PICUs). We …
unexplained inflammation requiring admission to paediatric intensive care units (PICUs). We …
CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation
DP Inwald, A McDowall, MJ Peters, RE Callard… - Circulation …, 2003 - Am Heart Assoc
CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF
receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an …
receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an …
Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study
RG Khemani, L Smith, YM Lopez-Fernandez… - The Lancet …, 2019 - thelancet.com
Background Paediatric acute respiratory distress syndrome (PARDS) is associated with high
mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The …
mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The …
Haemodynamic support for paediatric septic shock: a global perspective
S Ranjit, N Kissoon, A Argent, D Inwald… - The Lancet Child & …, 2023 - thelancet.com
Septic shock is a leading cause of hospitalisation, morbidity, and mortality for children
worldwide. In 2020, the paediatric Surviving Sepsis Campaign (SSC) issued evidence …
worldwide. In 2020, the paediatric Surviving Sepsis Campaign (SSC) issued evidence …
Invasive pneumococcal disease
E Randle, N Ninis, D Inwald - … of Disease in Childhood-Education and …, 2011 - ep.bmj.com
Streptococcus pneumoniae, the pneumococcus, is a Gram-positive diplococcus with more
than 90 serotypes determined by the polysaccharide composition of its capsule. It is carried …
than 90 serotypes determined by the polysaccharide composition of its capsule. It is carried …
Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit
Objective: To audit current UK practice of the management of severe sepsis in children
against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life …
against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life …
[HTML][HTML] Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life …
Background Sepsis is one of the main reasons for non-elective admission to pediatric
intensive care units (PICUs), but little is known about determinants influencing outcome. We …
intensive care units (PICUs), but little is known about determinants influencing outcome. We …
Fluid overload at 48 hours is associated with respiratory morbidity but not mortality in a general PICU: retrospective cohort study
L Sinitsky, D Walls, S Nadel… - Pediatric critical care …, 2015 - journals.lww.com
Objective: Recent evidence suggests that fluid overload may be deleterious to critically ill
children. The purpose of this study was to investigate the association of early fluid overload …
children. The purpose of this study was to investigate the association of early fluid overload …