Secular changes and worldwide variations in incidence rates of colorectal cancer, along
with results from twin and migrant studies, provide compelling evidence that environmental …

The potential relationship between childhood obesity and earlier puberty onset has major
public health implications. Earlier menarche in girls is associated with increased risk of adult …

ABBREVIATIONS. DKA, diabetic ketoacidosis; TIDM, type 1 diabetes mellitus; LWPES,
Lawson Wilkins Pediatric Endocrine Society; ESPE, European Society for Paediatric …

Mellitus (GDM) was held in Chicago, IL, 11–13 November 2005 under the sponsorship of
the American Diabetes Association. The meeting provided a forum for review of new …

Abstract The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide
association (GWA) scan on seven diseases, including the multifactorial autoimmune disease …

Objective: To identify predictors of postnatal catch-up growth from birth to two years and its
relation to size and obesity at five years. Design: Regional prospective cohort study. Setting …

The major histocompatibility complex (MHC) on chromosome 6 is associated with
susceptibility to more common diseases than any other region of the human genome …

In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in
the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard) …

In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true
positive irrefutable linkage and association results have been rare to date. Recently, it has …

Inherited defects in signaling pathways downstream of the insulin receptor have long been
suggested to contribute to human type 2 diabetes mellitus. Here we describe a mutation in …