SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications

E Brown, HJL Heerspink, DJ Cuthbertson, JPH Wilding - The Lancet, 2021 - thelancet.com
SGLT2 inhibitors and GLP-1 receptor agonists are used in patients with type 2 diabetes as
glucose lowering therapies, with additional benefits of weight loss and blood pressure …

Diabetic peripheral neuropathy: epidemiology, diagnosis, and pharmacotherapy

Z Iqbal, S Azmi, R Yadav, M Ferdousi, M Kumar… - Clinical …, 2018 - Elsevier
Purpose Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy
worldwide, and its prevalence increases with the duration of diabetes. It affects …

Reduced physical activity in young and older adults: metabolic and musculoskeletal implications

KA Bowden Davies, S Pickles… - Therapeutic …, 2019 - journals.sagepub.com
Background: Although the health benefits of regular physical activity and exercise are well
established and have been incorporated into national public health recommendations, there …

Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study

A Dennis, M Wamil, J Alberts, J Oben… - BMJ open, 2021 - bmjopen.bmj.com
Objective To assess medium-term organ impairment in symptomatic individuals following
recovery from acute SARS-CoV-2 infection. Design Baseline findings from a prospective …

[HTML][HTML] Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists

DJ Cuthbertson, A Irwin, CJ Gardner, C Daousi… - PloS one, 2012 - journals.plos.org
Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are effective for obese patients with
type 2 diabetes mellitus (T2DM) because they concomitantly target obesity and …

Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and …

H Jones, VS Sprung, CJA Pugh… - The Journal of …, 2012 - academic.oup.com
Context: Nonalcoholic fatty liver disease may be evident in women with polycystic ovary
syndrome (PCOS), both conditions being associated with obesity and insulin resistance …

Effectiveness of metyrapone in treating Cushing's syndrome: a retrospective multicenter study in 195 patients

E Daniel, S Aylwin, O Mustafa, S Ball… - The Journal of …, 2015 - academic.oup.com
Background: Cushing's syndrome (CS) is a severe condition with excess mortality and
significant morbidity necessitating control of hypercortisolemia. There are few data …

Diagnosing and managing carcinoid heart disease in patients with neuroendocrine tumors: an expert statement

J Davar, HM Connolly, ME Caplin, M Pavel… - Journal of the American …, 2017 - jacc.org
Carcinoid heart disease is a frequent occurrence in patients with carcinoid syndrome and is
responsible for substantial morbidity and mortality. The pathophysiology of carcinoid heart …

Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise

DJ Cuthbertson, J Babraj, K Smith… - American Journal …, 2006 - journals.physiology.org
We hypothesized a differential activation of the anabolic signaling proteins protein kinase B
(PKB) and p70 S6 kinase (p70S6K) and subsequent differential stimulation of human …

Weight loss variability with SGLT2 inhibitors and GLP‐1 receptor agonists in type 2 diabetes mellitus and obesity: mechanistic possibilities

E Brown, JPH Wilding, TM Barber, U Alam… - Obesity …, 2019 - Wiley Online Library
We are facing a global epidemic of obesity and type 2 diabetes. Weight loss, in the context of
obesity and type 2 diabetes, may improve glycaemic control and weight‐related …