Insulin resistance in children: consensus, perspective, and future directions

C Levy-Marchal, S Arslanian, W Cutfield… - The Journal of …, 2010 - academic.oup.com
Objective: Emerging data indicate that insulin resistance is common among children and
adolescents and is related to cardiometabolic risk, therefore requiring consideration early in …

Long-term metabolic consequences of being born small for gestational age

C Levy-Marchal, D Jaquet, P Czernichow - Seminars in Neonatology, 2004 - Elsevier
This article reviews the evidence for fetal and early origins of type 2 diabetes, insulin
resistance, dyslipidaemia and obesity. Particular emphasis is given to the role of adipose …

Consequences of intrauterine growth and early neonatal catch-up growth

O Claris, J Beltrand, C Levy-Marchal - Seminars in perinatology, 2010 - Elsevier
The long-term consequences of small size at birth have been well described during the last
2 decades. It is important to assess the fetal growth velocity and to recognize that newborns …

Variation in FTO contributes to childhood obesity and severe adult obesity

C Dina, D Meyre, S Gallina, E Durand, A Körner… - Nature …, 2007 - nature.com
We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated)
gene on chromosome 16q12. 2 that is consistently strongly associated with early-onset and …

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

D Meyre, J Delplanque, JC Chèvre, C Lecoeur… - Nature …, 2009 - nature.com
We analyzed genome-wide association data from 1,380 Europeans with early-onset and
morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers …

[HTML][HTML] Experimental treatment with favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea

D Sissoko, C Laouenan, E Folkesson… - PLoS …, 2016 - journals.plos.org
Background Ebola virus disease (EVD) is a highly lethal condition for which no specific
treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak …

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

R Saxena, MF Hivert, C Langenberg, T Tanaka… - Nature …, 2010 - nature.com
Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose
tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine …

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

A Ichimura, A Hirasawa, O Poulain-Godefroy… - Nature, 2012 - nature.com
Free fatty acids provide an important energy source as nutrients, and act as signalling
molecules in various cellular processes,,,. Several G-protein-coupled receptors have been …

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

N Bouatia-Naji, A Bonnefond, C Cavalcanti-Proença… - Nature …, 2009 - nature.com
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we
identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a …

Prediction of childhood obesity by infancy weight gain: an individual‐level meta‐analysis

C Druet, N Stettler, S Sharp… - Paediatric and …, 2012 - Wiley Online Library
Summary Druet C, Stettler N, Sharp S, Simmons RK, Cooper C, Davey Smith G, Ekelund U,
Lévy‐Marchal C, Jarvelin M‐R, Kuh D, Ong KK. Prediction of childhood obesity by infancy …