Purpose Demographic, behavioral, and environmental factors have been associated with
increased risk of colorectal cancer (CRC). We reviewed the published evidence and …

Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …

It has long been recognized that people differ in their susceptibility to disease. Some of
these differences are ascribed to the concept that heritable traits modify the effects of …

Autosomal dominant periodic fever syndromes are characterized by unexplained episodes
of fever and severe localized inflammation. In seven affected families, we found six different …

To identify risk variants for lung cancer, we conducted a multistage genome-wide
association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting∼
1% of the adult population worldwide, with an estimated heritability of 60%. To identify …

Background Rheumatoid arthritis is a chronic inflammatory disease with a substantial
genetic component. Susceptibility to disease has been linked with a region on chromosome …

Background Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1
and PTPN22 are well-established susceptibility loci, other genes that confer a modest level …

Crohn disease is a chronic, inflammatory disease of the gastrointestinal tract. A locus of∼
250 kb at 5q31 (IBD5), was previously associated with susceptibility to Crohn disease, as …