The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose
inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It …

To assess factors influencing the success of whole-genome sequencing for mainstream
clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families …

Abstract HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of
the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that …

Remote sensing of the reflectance photoplethysmogram using a video camera typically
positioned 1 m away from the patient's face is a promising method for monitoring the vital …

Although genome-wide association studies (GWAS) have identified the existence of
numerous population-based cancer susceptibility loci, mechanistic insights remain limited …

Dimethyloxalylglycine (DMOG) is an inhibitor of prolyl-4-hydroxylase domain (PHD)
enzymes that regulate the stability of hypoxia-inducible factor (HIF). We investigated the …

Fully activated innate immune cells are required for effective responses to infection, but their
prompt deactivation and removal are essential for limiting tissue damage. Here, we have …

INTRODUCTION: Regular exercise induces recurrent increases in cerebrovascular
perfusion. In peripheral arteries, such episodic increases in perfusion are responsible for …

Current monitoring systems available to track changes in the vital signs of patients (such as
heart rate, respiratory rate or peripheral oxygen saturation) require contact with the subject …

Background Whole genome sequencing is increasingly being used for the diagnosis of
patients with rare diseases. However, the diagnostic yields of many studies, particularly …