Diabetic neuropathy: clinical manifestations and current treatments
BC Callaghan, HT Cheng, CL Stables… - The lancet …, 2012 - thelancet.com
Diabetic peripheral neuropathy is a prevalent, disabling disorder. The most common
manifestation is distal symmetrical polyneuropathy (DSP), but many patterns of nerve injury …
manifestation is distal symmetrical polyneuropathy (DSP), but many patterns of nerve injury …
Diabetic neuropathy: cellular mechanisms as therapeutic targets
AM Vincent, BC Callaghan, AL Smith… - Nature Reviews …, 2011 - nature.com
In patients with diabetes, nerve injury is a common complication that leads to chronic pain,
numbness and substantial loss of quality of life. Good glycemic control can decrease the …
numbness and substantial loss of quality of life. Good glycemic control can decrease the …
Taking stock of the assisted migration debate
Assisted migration was proposed several decades ago as a means of addressing the
impacts of climate change on species populations. While its risks and benefits have been …
impacts of climate change on species populations. While its risks and benefits have been …
[HTML][HTML] Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis
C Figueroa-Romero, J Hur, DE Bender, CE Delaney… - PloS one, 2012 - journals.plos.org
Amyotrophic lateral sclerosis (ALS) is a terminal disease involving the progressive
degeneration of motor neurons within the motor cortex, brainstem and spinal cord. Most …
degeneration of motor neurons within the motor cortex, brainstem and spinal cord. Most …
[BOOK][B] Colonial memory and postcolonial Europe: Maltese settlers in Algeria and France
AL Smith - 2006 - books.google.com
"[I] ntersects with very active areas of research in history and anthropology, and links these
domains of inquiry spanning Europe and North Africa in a creative and innovative fashion." …
domains of inquiry spanning Europe and North Africa in a creative and innovative fashion." …
Monteiro's Storm‐petrel Oceanodroma monteiroi: a new species from the Azores
The existence of two seasonally distinct breeding populations of Oceanodroma storm‐
petrels in the Azores islands was first documented in 1996. The discovery of morphological …
petrels in the Azores islands was first documented in 1996. The discovery of morphological …
Vamorolone trial in Duchenne muscular dystrophy shows dose-related improvement of muscle function
EP Hoffman, BD Schwartz, LJ Mengle-Gaw, EC Smith… - Neurology, 2019 - AAN Enterprises
Objective To study vamorolone, a first-in-class steroidal anti-inflammatory drug, in Duchenne
muscular dystrophy (DMD). Methods An open-label, multiple-ascending-dose study of …
muscular dystrophy (DMD). Methods An open-label, multiple-ascending-dose study of …
[HTML][HTML] Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug
LS Conklin, JM Damsker, EP Hoffman, WJ Jusko… - Pharmacological …, 2018 - Elsevier
We report a first-in-patient study of vamorolone, a first-in-class dissociative steroidal anti-
inflammatory drug, in Duchenne muscular dystrophy. This 2-week, open-label Phase IIa …
inflammatory drug, in Duchenne muscular dystrophy. This 2-week, open-label Phase IIa …
Effects of climate change on the distribution of invasive alien species in Canada: a knowledge synthesis of range change projections in a warming world
The interactive effects of climate change and invasive alien species (IAS) pose serious
threats to biodiversity, ecosystems and human well-being worldwide. In particular, IAS are …
threats to biodiversity, ecosystems and human well-being worldwide. In particular, IAS are …
Why do smokers try to quit without medication or counselling? A qualitative study with ex-smokers
Objective When tobacco smokers quit, between half and two-thirds quit unassisted: that is,
they do not consult their general practitioner (GP), use pharmacotherapy (nicotine …
they do not consult their general practitioner (GP), use pharmacotherapy (nicotine …