Background: A sensitive and acceptable screening regimen for women at high risk for breast
cancer is essential. Contrast-enhanced magnetic resonance imaging (MRI) of the breast is …

Each year in the United States, breast cancer is diagnosed in more than 170,000 women. 1
Despite this substantial burden of disease, however, assessment of breast-cancer risk has …

Breast cancer risk assessment provides an estimation of disease risk that can be used to
guide management for women at all levels of risk. In addition, the likelihood that breast …

BACKGROUND: The availability of genetic testing for inherited mutations in the BRCA1
gene provides potentially valuable information to women at high risk of breast or ovarian …

Contralateral Breast Cancer in BRCA1 and BRCA2 Mutation Carriers Page 1 Contralateral
Breast Cancer in BRCA1 and BRCA2 Mutation Carriers Kelly Metcalfe, Henry T. Lynch, Parviz …

Purpose The purposes of this study were to estimate the reduction in risk of ovarian,
fallopian tube, or peritoneal cancer in women with a BRCA1 or BRCA2 mutation after …

Purpose The purpose of this study was to estimate the extent of protection offered against
breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and …

Purpose Bilateral prophylactic oophorectomy (BPO) is widely used for cancer risk reduction
in women with BRCA1/2 mutations. Many premenopausal women choose to take hormone …

Background The randomized, double-blind OlympiA trial compared 1 year of the oral poly
(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as …

Purpose An accurate evaluation of the penetrance of BRCA1 and BRCA2 mutations is
essential to the identification and clinical management of families at high risk of breast and …