Although the multifactorial nature of osteoarthritis (OA) is well recognized, genetic factors
have been found to be strong determinants of the disease. Evidence of a genetic influence …

The challenge faced by research into the genetic basis of complex disease is to identify
genes of small relative effect against a background of substantial genetic and environmental …

Objective. This study examines the reported evidence of an association between benign
joint hypermobility syndrome (BJHS) and psychological symptoms. Methods. A systematic …

Objective. To determine the relative effects of genetic and environmental factors in
susceptibility to ankylosing spondylitis (AS). Methods. Twins with AS were identified from the …

Objective Degenerative intervertebral disc disease is common; however, the importance of
genetic factors is unknown. This study sought to determine the extent of genetic influences …

The classic twin study is sometimes described as “the perfect natural experiment” for the
investigation of the aetiology of complex disease, but assumptions of the twin design need to …

Migraine is a common neurovascular brain disorder that is manifested in recurrent episodes
of disabling headache. The aim of the present study was to compare the prevalence and …

A classical twin study was performed to assess the extent to which genetic factors explain
individual differences in age at menopause and (indications for) hysterectomy. It was further …

Objective Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear
which individuals develop it. The authors examined the contribution of genetic factors …

Background Death within 90 days after total hip replacement is rare but might be avoidable
dependent on patient and treatment factors. We assessed whether a secular decrease in …