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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1969 3
1970 1
1972 1
1975 2
1979 1
1984 2
1985 1
1991 1
1992 4
1993 1
1994 3
1995 2
1997 1
1998 1
2000 1
2001 2
2003 1
2005 1
2006 1
2008 1
2013 1
2014 1
2016 2
2017 4
2018 2
2019 4
2020 3
2021 8
2022 11
2023 5
2024 6

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75 results

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Page 1
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.
Gallo D, Young JTF, Fourtounis J, Martino G, Álvarez-Quilón A, Bernier C, Duffy NM, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah PS, Fortin AB, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugère-Desjardins C, Goullet de Rugy T, Leclaire ME, Liu B, Bhaskaran V, Mamane Y, Melo H, Nicolas O, Singhania A, Szilard RK, Tkáč J, Yin SY, Morris SJ, Zinda M, Marshall CG, Durocher D. Gallo D, et al. Among authors: leclaire me. Nature. 2022 Apr;604(7907):749-756. doi: 10.1038/s41586-022-04638-9. Epub 2022 Apr 20. Nature. 2022. PMID: 35444283 Free PMC article.
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
Szychowski J, Papp R, Dietrich E, Liu B, Vallée F, Leclaire ME, Fourtounis J, Martino G, Perryman AL, Pau V, Yin SY, Mader P, Roulston A, Truchon JF, Marshall CG, Diallo M, Duffy NM, Stocco R, Godbout C, Bonneau-Fortin A, Kryczka R, Bhaskaran V, Mao D, Orlicky S, Beaulieu P, Turcotte P, Kurinov I, Sicheri F, Mamane Y, Gallant M, Black WC. Szychowski J, et al. Among authors: leclaire me. J Med Chem. 2022 Aug 11;65(15):10251-10284. doi: 10.1021/acs.jmedchem.2c00552. Epub 2022 Jul 26. J Med Chem. 2022. PMID: 35880755 Free PMC article.
Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
Bubenik M, Mader P, Mochirian P, Vallée F, Clark J, Truchon JF, Perryman AL, Pau V, Kurinov I, Zahn KE, Leclaire ME, Papp R, Mathieu MC, Hamel M, Duffy NM, Godbout C, Casas-Selves M, Falgueyret JP, Baruah PS, Nicolas O, Stocco R, Poirier H, Martino G, Fortin AB, Roulston A, Chefson A, Dorich S, St-Onge M, Patel P, Pellerin C, Ciblat S, Pinter T, Barabé F, El Bakkouri M, Parikh P, Gervais C, Sfeir A, Mamane Y, Morris SJ, Black WC, Sicheri F, Gallant M. Bubenik M, et al. Among authors: leclaire me. J Med Chem. 2022 Oct 13;65(19):13198-13215. doi: 10.1021/acs.jmedchem.2c00998. Epub 2022 Sep 20. J Med Chem. 2022. PMID: 36126059 Free PMC article.
RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.
Roulston A, Zimmermann M, Papp R, Skeldon A, Pellerin C, Dumas-Bérube É, Dumais V, Dorich S, Fader LD, Fournier S, Li L, Leclaire ME, Yin SY, Chefson A, Alam H, Yang W, Fugère-Desjardins C, Vignini-Hammond S, Skorey K, Mulani A, Rimkunas V, Veloso A, Hamel M, Stocco R, Mamane Y, Li Z, Young JTF, Zinda M, Black WC. Roulston A, et al. Among authors: leclaire me. Mol Cancer Ther. 2022 Feb;21(2):245-256. doi: 10.1158/1535-7163.MCT-21-0615. Epub 2021 Dec 15. Mol Cancer Ther. 2022. PMID: 34911817 Free PMC article.
Lipofuscin-dependent stimulation of microglial cells.
Leclaire MD, Nettels-Hackert G, König J, Höhn A, Grune T, Uhlig CE, Hansen U, Eter N, Heiduschka P. Leclaire MD, et al. Graefes Arch Clin Exp Ophthalmol. 2019 May;257(5):931-952. doi: 10.1007/s00417-019-04253-x. Epub 2019 Jan 28. Graefes Arch Clin Exp Ophthalmol. 2019. PMID: 30693383
Shock After Myocardial Infarction.
Williams DM, Shroff GR, Leclaire MM, Leatherman JW. Williams DM, et al. Among authors: leclaire mm. Chest. 2018 Feb;153(2):e29-e31. doi: 10.1016/j.chest.2017.10.045. Chest. 2018. PMID: 29406236 No abstract available.
Allergies - A T cells perspective in the era beyond the TH1/TH2 paradigm.
Berker M, Frank LJ, Geßner AL, Grassl N, Holtermann AV, Höppner S, Kraef C, Leclaire MD, Maier P, Messerer DA, Möhrmann L, Nieke JP, Schoch D, Soll D, Woopen CM. Berker M, et al. Among authors: leclaire md. Clin Immunol. 2017 Jan;174:73-83. doi: 10.1016/j.clim.2016.11.001. Epub 2016 Nov 12. Clin Immunol. 2017. PMID: 27847316 Review.
75 results