Relation of maternal blood pressure during pregnancy to birth weight and blood pressure in children. The Hypertension in Pregnancy Offspring Study

J Intern Med. 1994 Apr;235(4):347-52. doi: 10.1111/j.1365-2796.1994.tb01085.x.

Abstract

Objective: To evaluate the importance of perinatal factors, e.g. low birth weight, reduced gestational period and elevated maternal blood pressure during pregnancy, as well as high maternal blood pressure at follow-up 7-12 years after pregnancy, on blood pressure in children born after normotensive and hypertensive pregnancies.

Design: Follow-up study in children from hypertensive pregnancies and a control group of children born after normotensive pregnancies.

Setting: University Hospital, Göteborg, Sweden.

Subjects: Thirty-six children born after hypertensive pregnancies and a control group of 17 children born after normotensive pregnancies were studied at a mean age of 12.5 years.

Main outcome measure: Blood pressure.

Results: Systolic blood pressure was higher in children born after hypertensive pregnancies. They also had lower birth weight and a shorter gestational period. There was a negative correlation between the highest recorded maternal blood pressure during pregnancy and birth weight of the child and a positive correlation between maternal blood pressure and blood pressure in their offspring. No correlation was found between birth weight and blood pressure in these children.

Conclusions: Children born after hypertensive pregnancies have higher blood pressure compared to children born after normotensive pregnancies. There is a positive relationship between childhood blood pressure and maternal blood pressure during pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Birth Weight / physiology*
  • Blood Pressure / physiology*
  • Child
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Hypertension / embryology*
  • Hypertension / physiopathology
  • Male
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / physiopathology*